Charlet de Sauvage R, Aran J M, Erre J P
Hear Res. 1987;29(2-3):105-15. doi: 10.1016/0378-5955(87)90159-6.
The compound action potential (CAP) recorded at the round window has for some time been investigated in order to determine the underlying temporal spike sequence: the firing probability density (FPD) function of the fibres. Charlet de Sauvage et al. [(1980) Hear. Res. 2, 343-346; (1983) J. Acoust. Soc. Am. 73, 616-627] have previously described a close estimate of the far-field unit response (UR) by presenting to the ear a transient electrical stimulation combined with an acoustical masking noise. A linear model of UR, free of noise or extrinsic potentials and based on both experimental data and on the dipole principle of Teas et al. [(1962) J. Acoust. Soc. Am. 34, 1438-1459], was proposed [(1985) Hear. Res. 18, 121-125]. Using the UR model, deconvolutions were performed on CAPs recorded in various conditions of stimulation and of cochlear pathologies in the guinea pig. The principal findings were: (1) a plateau was observed in the amplitude function around 60-70 dB above normal threshold both for click-evoked CAPs and for the corresponding FPDs; (2) FPDs resulting from the deconvolution of high-frequency derived responses showed 2 main peaks with a 0.7 ms interval followed by a second homologous pair with lower amplitude. Convolution computations confirmed the need for the second set with peaks 2 and 3 being only 0.3 ms apart. These findings are interpreted in terms of mechanical excitation pattern.
为了确定潜在的时间尖峰序列，即纤维的放电概率密度（FPD）函数，人们对在圆窗记录的复合动作电位（CAP）进行了一段时间的研究。夏莱·德索瓦热等人[（1980年）《听觉研究》2，343 - 346；（1983年）《美国声学学会杂志》73，616 - 627]此前曾描述过一种通过向耳朵施加瞬态电刺激并结合声学掩蔽噪声来对远场单位反应（UR）进行近似估计的方法。提出了一种UR的线性模型，该模型无噪声或外在电位，基于实验数据以及蒂斯等人[（1962年）《美国声学学会杂志》34，1438 - 1459]的偶极子原理[（1985年）《听觉研究》18，121 - 125]。利用UR模型，对在豚鼠的各种刺激条件和耳蜗病变情况下记录的CAP进行了去卷积处理。主要发现如下：（1）对于短声诱发的CAP及其相应的FPD，在高于正常阈值约60 - 70 dB的幅度函数中观察到一个平台；（2）高频衍生反应去卷积得到的FPD显示出2个主峰，间隔为0.7 ms，随后是第二对幅度较低的同源峰。卷积计算证实了需要第二组峰，峰2和峰3之间仅相隔0.3 ms。这些发现是根据机械激发模式来解释的。
