Dolan D F, Nuttall A L, Avinash G
Kresge Hearing Research Institute, University of Michigan, Ann Arbor 48109-0506.
J Acoust Soc Am. 1990 Jun;87(6):2621-7. doi: 10.1121/1.399054.
Voltage recorded from an electrode on the round window (RW) of guinea pig has characteristics that reflect the activity of auditory-nerve fibers in the absence of acoustic stimulation. Fast Fourier transformation (FFT) of the noise recorded from the RW electrode shows a broad spectral peak from 0.8-1.0 kHz. The magnitude of the biological noise is increased by high-frequency, bandlimited acoustic noise stimulation. Pure tones can suppress or enhance the spectral components around 0.8-1.0 kHz depending on frequency and intensity. Kainic acid applied to the intact RW membrane eliminates the biological noise (and the evoked cochlear whole-nerve responses) without alteration of the cochlear microphonic or the summating potential. The spectral characteristics of the biological noise seem to be related to the elemental waveform contributed by the individual auditory-nerve fibers to the voltage recorded at the RW electrode [Kiang et al., Electrocochleography, edited by R. J. Ruben, C. Elbering, and G. Solomon (University Park, Baltimore, 1976)].
从豚鼠圆窗（RW）上的电极记录到的电压具有一些特性，这些特性反映了在没有声刺激时听神经纤维的活动。对从RW电极记录到的噪声进行快速傅里叶变换（FFT）显示，在0.8 - 1.0千赫兹范围内有一个宽频谱峰值。生物噪声的幅度会因高频、带限声噪声刺激而增加。纯音可根据频率和强度抑制或增强0.8 - 1.0千赫兹左右的频谱成分。将 kainic 酸应用于完整的RW膜可消除生物噪声（以及诱发的耳蜗全神经反应），而不会改变耳蜗微音器电位或总和电位。生物噪声的频谱特性似乎与单个听神经纤维对RW电极记录的电压所贡献的基本波形有关[江等，《电耳蜗图》，由R. J. 鲁本、C. 埃尔伯林和G. 所罗门编辑（巴尔的摩大学公园出版社，1976年）]。
