Prijs V F
Hear Res. 1986;21(2):127-33. doi: 10.1016/0378-5955(86)90034-1.
In guinea pigs the unit contribution (unit action potential, ap) to the response of the round window was computed following the method used by Kiang and co-workers (1976), i.e., fibre discharges registered by a microelectrode in the nerve were used as trigger pulses for the averaging process of the corresponding ap registered with a gross electrode at the round window. Normally the ap was independent of the fibre-CF, had a diphasic waveform, and its amplitude was about 0.1 microV. Small inter-animal differences were found in waveform and amplitude of the ap. In a pilot experiment exploring pathological influences on ap, the auditory nerve was stretched to mimic the effect of some acoustic nerve tumors. We found that the waveforms of both ap and compound action potential (CAP) changed. The results indicate that in normal guinea pig cochleas the existence of an elementary unit waveform can be used in the convolution of the CAP [Goldstein, M.H. Jr. and Kiang, N.Y.S. (1958) J. Acoust. Soc. Am. 30, 107-114]. In abnormal cochleas, however, deteriorated aps may disturb the simple convolution concept of the CAP.
在豚鼠中，按照江及其同事（1976年）所采用的方法计算了圆窗反应的单位贡献（单位动作电位，ap），即，将微电极在神经中记录到的纤维放电用作触发脉冲，对在圆窗处用粗电极记录到的相应ap进行平均处理。正常情况下，ap与纤维特征频率（CF）无关，具有双相波形，其幅度约为0.1微伏。在ap的波形和幅度方面发现了动物个体间的微小差异。在一项探索对ap的病理影响的预实验中，对听神经进行拉伸以模拟某些听神经瘤的效应。我们发现ap和复合动作电位（CAP）的波形都发生了变化。结果表明，在正常豚鼠耳蜗中，基本单位波形的存在可用于CAP的卷积计算[小戈尔茨坦，M.H.和江，N.Y.S.（1958年）《美国声学学会杂志》30，107 - 114]。然而，在异常耳蜗中，恶化的ap可能会干扰CAP的简单卷积概念。
