硬骨鱼类中枢神经系统免疫的已知和未知。
The knowns and many unknowns of CNS immunity in teleost fish.
机构信息
Center for Evolutionary and Theoretical Immunology, Department of Biology, University of New Mexico, Albuquerque, NM 87131, USA.
Center for Evolutionary and Theoretical Immunology, Department of Biology, University of New Mexico, Albuquerque, NM 87131, USA.
出版信息
Fish Shellfish Immunol. 2022 Dec;131:431-440. doi: 10.1016/j.fsi.2022.10.013. Epub 2022 Oct 12.
Many disease agents infect the central nervous system (CNS) of teleost fish causing severe losses for the fish farming sector. Yet, neurotropic fish pathogens remain poorly documented and immune responses in the teleost CNS essentially unknown. Previously thought to be devoid of an immune system, the mammalian CNS is now recognized to be protected from infection by diverse immune cells that mostly reside in the meningeal lymphatic system. Here we review the current body of work pertaining immune responses in the teleost CNS to infection. We identify important knowledge gaps with regards to CNS immunity in fish and make recommendations for rigorous experimentation and reporting in manuscripts so that fish immunologists can advance this burgeoning field.
许多病原体感染鱼类的中枢神经系统（CNS），给鱼类养殖业造成了严重的损失。然而，神经亲和性鱼类病原体的相关研究仍然很少，鱼类中枢神经系统的免疫反应也基本未知。人们曾认为哺乳动物的中枢神经系统没有免疫系统，但现在发现它受到多种免疫细胞的保护，而这些免疫细胞主要存在于脑膜淋巴系统中。在这里，我们回顾了有关鱼类中枢神经系统对感染的免疫反应的现有研究。我们确定了鱼类中枢神经系统免疫方面的重要知识空白，并就严格的实验和论文报告提出了建议，以使鱼类免疫学家能够推动这一新兴领域的发展。
Zotero 插件