揭示与体力活动/运动训练相关的 miRNA 在癌症中的反应：系统综述。
Unveiling the miRNAs responsive to physical activity/exercise training in cancer: A systematic review.
机构信息
Dipartimento di Scienze Motorie e del Benessere, Università degli studi di Napoli Parthenope, Naples, Italy; CEINGE - Biotecnologie Avanzate S.c.a.r.l., Naples, Italy.
Dipartimento di Scienze Motorie e del Benessere, Università degli studi di Napoli Parthenope, Naples, Italy.
出版信息
Crit Rev Oncol Hematol. 2022 Dec;180:103844. doi: 10.1016/j.critrevonc.2022.103844. Epub 2022 Oct 13.
PURPOSE
Since cancer-related miRNAs expression are affected by physical activity/exercise, they represent an attractive tool to monitor this response in healthy and in cancer subjects. Here, we aim to update the literature regarding the benefit of this axis in oncology field.
METHOD
We systematically questioned the literature according to PRISMA guidelines defining our questions by PICO tool and carrying out the risk of bias and quality assessment by NOS.
RESULTS
Among 751 records risen from the initial search, 28 studies resulted eligible. The majority of studies regarded breast cancer, while others were initially conducted in healthy subjects and afterwards authors speculated on the relationship between exercise-modulated miRNAs and cancer.
CONCLUSION
Physical activity/exercise induces beneficial effects in the cancer prevention, prognosis and treatments. Among the miRNAs modulated by physical activity/exercise, miR-21, let-7 and miR-133 families resulted the most promising in this field.
目的
由于癌症相关 miRNA 的表达受身体活动/运动的影响，因此它们是监测健康人群和癌症患者中这种反应的一种有吸引力的工具。在这里，我们旨在更新该轴在肿瘤学领域的相关文献。
方法
我们根据 PRISMA 指南系统地查询文献，通过 PICO 工具定义我们的问题，并通过 NOS 进行偏倚风险和质量评估。
结果
从最初的搜索中出现了 751 条记录，其中 28 项研究符合条件。大多数研究涉及乳腺癌，而其他研究最初是在健康受试者中进行的，之后作者推测运动调节的 miRNA 与癌症之间的关系。
结论
身体活动/运动可预防癌症、改善预后和治疗效果。在身体活动/运动调节的 miRNA 中，miR-21、let-7 和 miR-133 家族在该领域最有希望。
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