Hossain Mohammad Enayet, Rahman Mohammed Ziaur, Islam Md Muzahidul, Hoque Ananya Ferdous, Sumiya Mariya Kibtiya, Begum Mst Noorjahan, Alam Mohammad Mamun, Uddin K M Main, Hassan Md Zakiul, Rahman Mustafizur, Goswami Doli Rani, Brooks W Abdullah
icddr,b, Infectious Diseases Division, Dhaka, Bangladesh.
Bloomberg School of Public, Department of International Health, Johns Hopkins University, United States.
Heliyon. 2022 Oct;8(10):e11043. doi: 10.1016/j.heliyon.2022.e11043. Epub 2022 Oct 11.
Epidemiological data of specific respiratory pathogens from the pre-COVID-19 period are essential to determine the effects of the COVID-19 pandemic on other respiratory infections. In this study, we revealed the pre-COVID-19 molecular epidemiology of respiratory syncytial virus (RSV) among children in Bangladesh. We tested 3170 samples collected from 2008 to 2012 for a panel of respiratory viruses; RSV, human metapneumovirus (hMPV), human parainfluenza viruses (hPIV) 1, 2, 3, and adenovirus. Five hundred fifty-five samples (17.5 %) were positive for RSV, including 2.5% having co-infections with other viruses. Genotypic characterization of RSV showed that RSV-A (82%) contributed more acute respiratory infections than RSV-B (18%). Clinical features were similar with RSV-A and RSV-B infections. However, children with RSV-B were more likely to have upper respiratory infections (URI) (10% vs. 29%, p = 0.03). Among RSV-A cases, hospitalization was higher for ON1 cases (25%, ON1 vs. 8%, NA1, p = 0.04), whereas the recovery without a disability was higher among the NA1 cases (56%, ON1 vs. 88%, NA1, p = 0.02). The time to the most recent common ancestor (TMRCA) for RSV in Bangladesh was 1949 for RSV-A and 1944 for RSV-B. This study revealed the genotypic diversity and evolutionary relatedness of RSV strains in Bangladesh and provided pre-COVID molecular epidemiology data to understand better the COVID-19 impact on upcoming RSV epidemiology in Bangladesh.
新冠疫情之前特定呼吸道病原体的流行病学数据对于确定新冠疫情对其他呼吸道感染的影响至关重要。在本研究中，我们揭示了孟加拉国儿童中呼吸道合胞病毒（RSV）在新冠疫情之前的分子流行病学情况。我们对2008年至2012年收集的3170份样本进行了一组呼吸道病毒检测；包括RSV、人偏肺病毒（hMPV）、人副流感病毒（hPIV）1、2、3型以及腺病毒。555份样本（17.5%）RSV呈阳性，其中2.5%与其他病毒合并感染。RSV的基因分型显示，RSV-A（82%）导致的急性呼吸道感染比RSV-B（18%）更多。RSV-A和RSV-B感染的临床特征相似。然而，RSV-B感染的儿童更易出现上呼吸道感染（URI）（10%对29%，p = 0.03）。在RSV-A病例中，ON1型病例的住院率更高（25%，ON1型对8%，NA1型，p = 0.04），而NA1型病例中无残疾康复的比例更高（56%，ON1型对88%，NA1型，p = 0.02）。孟加拉国RSV最近共同祖先的时间（TMRCA），RSV-A为1949年，RSV-B为1944年。本研究揭示了孟加拉国RSV毒株的基因多样性和进化相关性，并提供了新冠疫情之前的分子流行病学数据，以更好地了解新冠疫情对孟加拉国即将到来的RSV流行病学的影响。
