Yao Huankai, Yang Feng, Li Yan
Department of Microbial and Biochemical Pharmacy, School of Pharmacy, Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, Xuzhou, Jiangsu, China.
School of Stomatology, Xuzhou Medical University, Xuzhou, Jiangsu, China.
Front Chem. 2022 Sep 29;10:1013670. doi: 10.3389/fchem.2022.1013670. eCollection 2022.
Reprogramming cancer metabolism has become the hallmark of cancer progression. As the key enzyme catalyzing the conversion of pyruvate to lactate in aerobic glycolysis of cancer cells, human lactate dehydrogenase (LDH) has been a promising target in the discovery of anticancer agents. Natural products are important sources of new drugs. Up to now, some natural compounds have been reported with the activity to target LDH. To give more information on the development of LDH inhibitors and application of natural products, herein, we reviewed the natural compounds with inhibition of LDH from diverse structures and discussed the future direction of the discovery of natural LDH inhibitors for cancer therapy.
重编程癌症代谢已成为癌症进展的标志。作为癌细胞有氧糖酵解中催化丙酮酸转化为乳酸的关键酶，人乳酸脱氢酶（LDH）一直是抗癌药物发现中的一个有前景的靶点。天然产物是新药的重要来源。到目前为止，已有一些天然化合物被报道具有靶向LDH的活性。为了提供更多关于LDH抑制剂开发和天然产物应用的信息，在此，我们综述了具有LDH抑制活性的不同结构的天然化合物，并讨论了用于癌症治疗的天然LDH抑制剂发现的未来方向。
