Paracha Mariam, Herbst Konnor, Kieburtz Karl, Venuto Charles S
Center for Health + Technology University of Rochester Rochester New York USA.
Department of Science and Mathematics National Technical Institute for the Deaf, Rochester Institute of Technology Rochester New York USA.
Mov Disord Clin Pract. 2022 Aug 18;9(7):961-966. doi: 10.1002/mdc3.13533. eCollection 2022 Oct.
The prevalence ratio (PR) and incidence rate ratio (IRR) of nonmotor symptoms (NMS) were calculated for early Parkinson's disease (PD) versus non-PD from 2 observational studies.
NMS were assessed through the self-reported Non-Motor Symptom Questionnaire in the online Fox Insight study and through self- and clinician-rated scales in the Parkinson's Progression Marker Initiative (PPMI) study. Age- and sex-adjusted/matched PR and IRR were estimated for each NMS by PD status using Poisson regression.
Most NMS occurred more frequently in PD. Among 15,194 Fox Insight participants, sexual dysfunction had the largest adjusted PR (12.4 [95% CI, 6.9-22.2]) and dysgeusia/hyposmia had the largest adjusted IRR over a 2-year median follow-up (17.0 [95% CI, 7.8-37.1]). Among 607 PPMI participants, anosmia had the largest PR (16.6 [95% CI, 6.1-44.8]). During the 7-year median follow-up, hallucinations had the largest IRR (13.5 [95% CI, 6.3-28.8]).
Although many NMS are more common in early PD than in non-PD, their occurrence may differ with time (hallucinations) or data collection methods (sexual dysfunction).
从两项观察性研究中计算早期帕金森病（PD）与非帕金森病患者非运动症状（NMS）的患病率比（PR）和发病率比（IRR）。
在在线Fox Insight研究中通过自我报告的非运动症状问卷评估NMS，并在帕金森病进展标志物倡议（PPMI）研究中通过自我和临床医生评定量表进行评估。使用泊松回归按PD状态对每个NMS估计年龄和性别调整/匹配的PR和IRR。
大多数NMS在PD中出现得更频繁。在15194名Fox Insight参与者中，性功能障碍的调整后PR最大（12.4 [95%CI，6.9 - 22.2]），在两年中位随访期间味觉障碍/嗅觉减退的调整后IRR最大（17.0 [95%CI，7.8 - 37.1]）。在607名PPMI参与者中，嗅觉丧失的PR最大（16.6 [95%CI，6.1 - 44.8]）。在7年中位随访期间，幻觉的IRR最大（13.5 [95%CI，6.3 - 28.8]）。
尽管许多NMS在早期PD中比在非PD中更常见，但其发生可能随时间（幻觉）或数据收集方法（性功能障碍）而有所不同。
