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Inhibition of gastric secretion and stress-induced ulcers by intravenous Asu(1,7)eel-calcitonin independent of vasopressin.

作者信息

Clementi G, Prato A, Conforto G, Rapisarda E, Caruso A, Mangano O, Scapagnini U

出版信息

J Endocrinol Invest. 1987 Jun;10(3):225-8. doi: 10.1007/BF03348115.

DOI:10.1007/BF03348115
PMID:3624798
Abstract

The effects of different doses of Asu(1,7) eel-calcitonin, peripherally injected, on gastric secretion were studied in conscious Brattleboro rats, which are genetically deficient in vasopressin. Moreover, we evaluated the activity of this analogue on gastric ulcer formation by restraint stress. We found that 5 IU/kg Asu(1,7) eel-calcitonin decreased gastric secretion and inhibited the development of stress-induced ulcers in Brattleboro rats. These data suggest that vasopressin does not play a role in the gastrointestinal activity of Asu(1,7) eel-calcitonin.

摘要

相似文献

1
Inhibition of gastric secretion and stress-induced ulcers by intravenous Asu(1,7)eel-calcitonin independent of vasopressin.
J Endocrinol Invest. 1987 Jun;10(3):225-8. doi: 10.1007/BF03348115.
2
Inhibition of restraint stress by systemic (Asu1,7) eel-calcitonin.
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3
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本文引用的文献

1
VASOPRESSIN AND GASTRIC SECRETION.血管加压素与胃液分泌
Surg Forum. 1964;15:118-20.
2
Intraventricular calcitonin inhibits gastric acid secretion.脑室内降钙素抑制胃酸分泌。
Science. 1981 Nov 6;214(4521):671-3. doi: 10.1126/science.7292006.
3
Prostaglandin E2: a neuromodulator in the central control of gastrointestinal motility and feeding behavior by calcitonin.前列腺素E2：降钙素对胃肠蠕动和摄食行为进行中枢控制时的一种神经调质。
Science. 1984 Sep 7;225(4666):1050-2. doi: 10.1126/science.6591429.
4
Effects of [Asu1,7]-eel calcitonin on gastric somatostatin and gastrin release.[Asu1,7]-鳗鱼降钙素对胃生长抑素和胃泌素释放的影响。
Gut. 1980 Feb;21(2):94-7. doi: 10.1136/gut.21.2.94.
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Effect of exogenous and endogenous prostaglandin E upon gastric endocrine function in dogs.外源性和内源性前列腺素E对犬胃内分泌功能的影响。
Endocrinology. 1980 May;106(5):1620-7. doi: 10.1210/endo-106-5-1620.
6
Centrally administered PGE2 inhibits gastric secretion in the rat by releasing vasopressin.中枢给予的前列腺素E2通过释放血管加压素抑制大鼠的胃酸分泌。
Eur J Pharmacol. 1984 Sep 3;104(1-2):145-50. doi: 10.1016/0014-2999(84)90381-9.
7
Gastric ulcers induced by acid accumulation and by stress in pylorus-occluded rats.幽门结扎大鼠因胃酸积聚和应激诱导的胃溃疡。
Eur J Pharmacol. 1974 Apr;26(1):15-21. doi: 10.1016/0014-2999(74)90068-5.
8
A new method for the collection of gastric secretion in conscious rats.一种在清醒大鼠中收集胃分泌液的新方法。
Pflugers Arch. 1972;336(2):111-20. doi: 10.1007/BF00592926.
9
Inhibition of restraint stress by systemic (Asu1,7) eel-calcitonin.
J Endocrinol Invest. 1985 Dec;8(6):543-6. doi: 10.1007/BF03348558.