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系统性红斑狼疮患者中Th17细胞、调节性T细胞及相关细胞因子的失衡：一项荟萃分析

Imbalance of Th17 cells, Treg cells and associated cytokines in patients with systemic lupus erythematosus: a meta-analysis.

作者信息

Huang Jinge, Li Xiaolong, Zhu Qingmiao, Wang Meijiao, Xie Zhijun, Zhao Ting

机构信息

The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, China.

College of Basic Medical Sciences, Zhejiang Chinese Medical University, Hangzhou, China.

出版信息

Front Immunol. 2024 Jul 17;15:1425847. doi: 10.3389/fimmu.2024.1425847. eCollection 2024.

DOI:10.3389/fimmu.2024.1425847
PMID:39086480
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11288813/
Abstract

OBJECTIVE

This article aims to investigate the changes of T helper 17 (Th17) cells, regulatory T (Treg) cells and their associated cytokines in patients with systemic lupus erythematosus (SLE).

METHODS

Multiple databases were investigated to identify articles that explored Th17 cells, Treg cells and relevant cytokines in SLE patients. A random effects model was used for calculating pooled standardized mean differences. Stata version 15.0 was utilized to conduct the meta-analysis.

RESULTS

The levels of Th17 cells, IL-17, IL-6, IL-21 and IL-10 were higher in SLE patients than in healthy controls (HCs), but the TGF-β levels were lower. The percentage of Treg cells was lower than HCs in SLE individuals older than 33. Among studies that had 93% or lower females, the percentage of Th17 cells was greater in patients than in HCs. However, the percentage of Treg cells was lower when the proportion of females was less than 90%. Patients with lupus nephritis or active SLE had an increased proportion of Th17 cells and a decreased proportion of Treg cells.

CONCLUSIONS

The increased level of Th17 cells and related cytokines could be the main reason for the elevated Th17/Treg ratio in SLE. The percentages of Th17 and Treg cells were associated with gender, age, disease activity and kidney function. Furthermore, the reduced proportions of Treg cells may primarily result in a rise in the Th17/Treg ratio in older or active SLE patients.

SYSTEMATIC REVIEW REGISTRATION

https://www.crd.york.ac.uk/prospero, identifier CRD42023454937.

摘要

目的

本文旨在研究系统性红斑狼疮（SLE）患者中辅助性T细胞17（Th17）、调节性T（Treg）细胞及其相关细胞因子的变化。

方法

检索多个数据库，以识别探索SLE患者中Th17细胞、Treg细胞及相关细胞因子的文章。采用随机效应模型计算合并标准化均数差。使用Stata 15.0版本进行荟萃分析。

结果

SLE患者的Th17细胞、白细胞介素-17（IL-17）、IL-6、IL-21和IL-10水平高于健康对照（HCs），但转化生长因子-β（TGF-β）水平较低。在年龄大于33岁的SLE个体中，Treg细胞百分比低于HCs。在女性比例为93%或更低的研究中，患者的Th17细胞百分比高于HCs。然而，当女性比例小于90%时，Treg细胞百分比更低。狼疮性肾炎或活动期SLE患者的Th17细胞比例增加，Treg细胞比例降低。

结论

Th17细胞及相关细胞因子水平升高可能是SLE中Th17/Treg比值升高的主要原因。Th17和Treg细胞百分比与性别、年龄、疾病活动度和肾功能有关。此外，Treg细胞比例降低可能主要导致老年或活动期SLE患者的Th17/Treg比值升高。

系统评价注册

https://www.crd.york.ac.uk/prospero，标识符CRD42023454937 。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0508/11288813/3e758e2d7dc7/fimmu-15-1425847-g010.jpg
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