Sakanashi T M, Brigham H E, Rasmussen K M
J Nutr. 1987 Aug;117(8):1469-74. doi: 10.1093/jn/117.8.1469.
Cardiac output, organ blood flow and organ weights were examined in rats assigned at d 0 of lactation to a control (C) group fed ad libitum or an acutely restricted (AR) group fed 50% of the intake of C dams. Dams in each group were assigned to subgroups for measurement of milk yield or cardiac output, blood flow and organ weights. At d 14 of lactation, cardiac output and blood flow were measured with radiolabeled microspheres and milk yield with the tritiated water method. In AR dams cardiac output was 55% of that of C dams, but cardiac output relative to body weight did not differ between groups. Mammary gland blood flow and weight were reduced in AR dams. The weight of the kidneys, gastrointestinal tract and liver of the AR dams was less than that of C dams; however, relative blood flow to these organs did not differ between groups. Milk yield was reduced by 58% in AR dams compared to C dams. We conclude that dietary restriction during lactation negatively affects absolute cardiac output, blood flow to the mammary glands and milk yield, and that the reduced milk yield is associated with the decrease in mammary gland weight and blood flow.
在哺乳期第0天，将大鼠分为两组：自由采食的对照组（C组）和采食为C组母鼠摄入量50%的急性限食组（AR组），检测两组大鼠的心输出量、器官血流量和器官重量。每组母鼠又分为亚组，分别用于测定产奶量或心输出量、血流量及器官重量。在哺乳期第14天，用放射性微球测定心输出量和血流量，用氚水法测定产奶量。AR组母鼠的心输出量为C组母鼠的55%，但两组的心输出量相对于体重无差异。AR组母鼠的乳腺血流量和重量降低。AR组母鼠的肾脏、胃肠道和肝脏重量低于C组母鼠；然而，两组这些器官的相对血流量无差异。与C组母鼠相比，AR组母鼠的产奶量降低了58%。我们得出结论，哺乳期的饮食限制对绝对心输出量、乳腺血流量和产奶量有负面影响，且产奶量降低与乳腺重量和血流量减少有关。
