Ahokas R A, Reynolds S L, Anderson G D, Lipshitz J
J Nutr. 1984 Dec;114(12):2262-8. doi: 10.1093/jn/114.12.2262.
Maternal organ distribution of cardiac output was measured with 15-micron diameter, radioactively labeled microspheres in ad libitum-fed or 50% diet-restricted, term pregnant rats, and in ad libitum-fed nonpregnant rats. The diet-restricted dams had a 33% lower total cardiac output than the ad libitum-fed dams, but it was not significantly different from that of the nonpregnant rats. Placental blood flow in the diet-restricted rats was 30% lower than that in the ad libitum-fed rats. Except for a higher blood flow to the pancreas and a lower blood flow to the uterine tissue, blood flows to the other organs of the diet-restricted dams were not significantly different from those of ad libitum-fed pregnant dams. Blood flows to the lungs, small intestine and ovaries of the diet-restricted pregnant rats were higher than those in the nonpregnant rats. Dietary restriction resulted in a decreased percentage of the cardiac output being distributed to the pregnant uterus and an increased percentage to the hepatic portal circulation, thus maintaining a liver blood flow similar to that in nonpregnant rats. Thus, maternal liver blood flow, rather than that to the placentas, is protected during malnutrition.
采用直径为15微米、放射性标记的微球，对自由采食或饮食限制50%的足月妊娠大鼠以及自由采食的非妊娠大鼠的心输出量在母体各器官中的分布情况进行了测量。饮食限制的母鼠总心输出量比自由采食的母鼠低33%，但与非妊娠大鼠相比无显著差异。饮食限制大鼠的胎盘血流量比自由采食大鼠低30%。除了流向胰腺的血流量较高以及流向子宫组织的血流量较低外，饮食限制母鼠其他器官的血流量与自由采食妊娠母鼠的血流量无显著差异。饮食限制妊娠大鼠流向肺、小肠和卵巢的血流量高于非妊娠大鼠。饮食限制导致分配到妊娠子宫的心输出量百分比降低，而分配到肝门循环的百分比增加，从而使肝脏血流量维持在与非妊娠大鼠相似的水平。因此，在营养不良期间，母体肝脏血流量而非胎盘血流量受到保护。
