用8-甲氧基补骨脂素和阳光治疗银屑病。

Treatment of psoriasis with 8-methoxypsoralen and sunlight.

作者信息

Robertson D B, McCarty J R, Jarratt M

出版信息

South Med J. 1978 Nov;71(11):1345-9. doi: 10.1097/00007611-197811000-00009.

DOI:10.1097/00007611-197811000-00009

Abstract

Photochemotherapy with 8-methoxypsoralen and sunlight (PUVA-SOL), administered three times weekly, proved effective in the treatment of psoriasis. Weekend photochemotherapy (modified PUVA-SOL) also appeared useful as an adjunct to standard topical corticosteroid therapy. Careful measurement of ambient long-wave ultraviolet light (UVA) in the treatment locale and respect for the phototoxic potential of PUVA-SOL are necessary for success. The long-range toxicity of psoralen photochemotherapy remains undetermined.

摘要

每周三次给予8-甲氧基补骨脂素和阳光进行光化学疗法（PUVA-SOL），已证明对治疗银屑病有效。周末光化学疗法（改良PUVA-SOL）作为标准外用皮质类固醇疗法的辅助手段似乎也有用。为取得成功，必须仔细测量治疗场所的环境长波紫外线（UVA）并重视PUVA-SOL的光毒性潜力。补骨脂素光化学疗法的长期毒性仍未确定。