Duquette P, Murray T J, Pleines J, Ebers G C, Sadovnick D, Weldon P, Warren S, Paty D W, Upton A, Hader W
J Pediatr. 1987 Sep;111(3):359-63. doi: 10.1016/s0022-3476(87)80454-7.
Multiple sclerosis (MS) has its usual onset in early adult life (average age of 30 years), but age at clinical onset varies considerably. The implications of the age of onset on the clinical presentation and course of MS are unclear. This population-based retrospective study presents data from a group of 125 patients with onset of MS before age 16 years and can thus be considered as representative of MS occurring in childhood. It demonstrates that childhood MS is more frequent in girls, that it very often has a relapsing-remitting course, that initial bouts usually involve afferent structures of the central nervous system, that recovery from these is often complete, and that the pace of the disease is slow.
多发性硬化症（MS）通常在成年早期发病（平均年龄30岁），但临床发病年龄差异很大。发病年龄对MS临床表现和病程的影响尚不清楚。这项基于人群的回顾性研究提供了一组125例16岁前发病的MS患者的数据，因此可被视为儿童期MS的代表。研究表明，儿童期MS在女孩中更为常见，通常具有复发-缓解病程，最初发作通常累及中枢神经系统的传入结构，这些发作后的恢复往往是完全的，且疾病进展缓慢。
