Department of Otorhinolaryngology, Head and Neck Surgery, Hannover Medical School, Hannover, Germany.
Cluster of Excellence "Hearing4all" of the German Research Foundation, Hannover Medical School, Hannover, Germany.
Acta Otorhinolaryngol Ital. 2022 Aug;42(4):364-371. doi: 10.14639/0392-100X-N2074.
The goal of the study was to determine whether the level of OTOLIN-1, a protein whose expression is highly restricted to the inner ear,is increased in the body fluids of patients with inner ear disorders in comparison to healthy subjects.
In the preliminary part of the study, OTOLIN-1 levels were measured in the serum, urine, and saliva of patients with an acute onset of Ménière´s disease and in healthy individuals. Subsequently, only serum OTOLIN-1 levels were taken into account and were compared between patients with acute onset of Ménière´s disease, sudden hearing loss, vestibular neuritis and healthy subjects.
The most reliable diagnostic parameter was OTOLIN-1 levels in serum. Serum samples of patients with Ménière's disease and sudden hearing loss showed significantly higher OTOLIN-1 levels than those from healthy individuals. In addition, there was no significant difference between the serum concentration of OTOLIN-1 in patients with vestibular neuritis and the control group.
Serum levels of OTOLIN-1 can potentially be used as a biomarker for acute onset of inner ear disorders due to its significant increase in patients with acute Meniere´s disease and sudden hearing loss in comparison to healthy individuals.
本研究旨在确定蛋白 OTOLIN-1 的水平是否在患有内耳疾病的患者的体液中升高，与健康受试者相比，OTOLIN-1 是一种在内耳中高度受限表达的蛋白质。
在研究的初步部分，测量了突发性梅尼埃病患者和健康个体的血清、尿液和唾液中的 OTOLIN-1 水平。随后，仅考虑血清 OTOLIN-1 水平，并将其与突发性梅尼埃病、突发性聋、前庭神经炎患者与健康受试者进行比较。
最可靠的诊断参数是血清中的 OTOLIN-1 水平。梅尼埃病和突发性聋患者的血清样本中 OTOLIN-1 水平明显高于健康个体。此外，前庭神经炎患者的血清 OTOLIN-1 浓度与对照组之间无显著差异。
由于血清 OTOLIN-1 水平在突发性梅尼埃病和突发性聋患者中与健康个体相比显著升高，因此其可能成为内耳疾病急性发作的生物标志物。
