Laboratory of Genetics, Immunology, and Human Pathologies, Faculty of Science of Tunis, University Tunis El Manar, Tunis, Tunisia.
BIOMICs Research Group, Lascaray Research Center, University of the Basque Country UPV/EHU, Vitoria-Gasteiz, Spain.
Ann Hum Biol. 2022 Dec;49(7-8):342-347. doi: 10.1080/03014460.2022.2136755. Epub 2022 Nov 29.
Tunisia has a complex demographic history of migrations from within Africa, Europe, and the Middle East. However, only one population study based on X-STR markers has been reported so far.
To investigate the genetic polymorphisms of 17 X-STRs in two Tunisian populations from the cities of Sousse and Makthar, and to reveal the genetic relationships with other reference populations.
A total of 194 unrelated healthy individuals were analysed for 17 X-STR markers.
Our results indicate that DXS6809 is the most polymorphic locus, whereas DXS6807 is the least informative marker in the populations of Sousse and Makthar. In addition, forensic statistical parameters, such as the power of discrimination in males and females, as well as the mean of exclusion in duos and trios, reveal that the panel of 17 X-STRs is highly informative and useful in different forensic applications. Overall, pairwise genetic distances (Fst) and non-metric MDS plots demonstrate clustering of different populations according to their geographic locations and their historical relationships.
Overall, the study of X-STR markers of the Tunisian populations can help to promote the establishment of a forensic DNA reference database in Tunisia and provide reference for future anthropological research.
突尼斯的人口历史复杂，有来自非洲、欧洲和中东的移民。然而，迄今为止，仅有一项基于 X-STR 标记的人口研究报告。
研究突尼斯苏塞市和马卡塔市两个群体的 17 个 X-STR 遗传多态性，并揭示与其他参考群体的遗传关系。
对 194 名无关的健康个体进行了 17 个 X-STR 标记分析。
我们的结果表明，在苏塞和马卡塔人群中，DXS6809 是最具多态性的基因座，而 DXS6807 是最不具信息量的标记。此外，法医统计参数，如男性和女性的鉴别能力、二联体和三联体的平均排除率，表明 17 个 X-STR 标记面板在不同的法医应用中具有高度的信息性和有用性。总体而言，成对遗传距离（Fst）和非度量 MDS 图表明，不同群体根据地理位置和历史关系聚类。
总体而言，对突尼斯人群的 X-STR 标记的研究有助于促进突尼斯法医 DNA 参考数据库的建立，并为未来的人类学研究提供参考。
