Laboratory of Functionalized Molecular Solids, Ministry of Education, Anhui Key Laboratory of Chemo/Biosensing, Laboratory of Biosensing and Bioimaging (LOBAB), College of Chemistry and Materials Science, Anhui Normal University, Wuhu241002, P. R. China.
ACS Biomater Sci Eng. 2022 Nov 14;8(11):5018-5026. doi: 10.1021/acsbiomaterials.2c00986. Epub 2022 Oct 18.
Wound healing has remained a critical challenge due to its susceptibility to bacterial infection and the unique biological inflammatory response. Safe and effective therapeutics are still lacking. Biodegradable macromolecules (ε-polylysine--ferrocene, EPL--Fc) were developed to accelerate wound healing by combating bacterial infection and attenuating inflammatory responses. The biodegradable macromolecules were prepared a Schiff-based reaction between ferrocene carboxaldehyde (Fc) and ε-polylysine (EPL). Through the synergistic combination of positive-charged EPL and π-π stacked Fc, the macromolecules possess excellent antibacterial activities. EPL--Fc with catalase-like activity could modulate the oxidative microenvironment in mammalian cells and zebrafish by catalyzing HO into HO and O. EPL--Fc could alleviate inflammatory response . Furthermore, the macromolecules could accelerate bacteria-infected wound healing . This work provides a versatile strategy for repairing bacteria-infected wounds by eliminating bacteria, modulating oxidative microenvironment, and alleviating inflammatory response.
由于其易受细菌感染和独特的生物炎症反应的影响，伤口愈合仍然是一个关键的挑战。安全有效的治疗方法仍然缺乏。可生物降解的高分子（ε-聚赖氨酸-二茂铁，EPL-Fc）的开发是为了通过对抗细菌感染和减轻炎症反应来加速伤口愈合。可生物降解的高分子是通过二茂铁甲醛（Fc）和ε-聚赖氨酸（EPL）之间的席夫碱反应制备的。通过带正电荷的 EPL 和π-π 堆积的 Fc 的协同组合，这些高分子具有优异的抗菌活性。具有类过氧化物酶活性的 EPL-Fc 可以通过将 HO 转化为 HO 和 O 来调节哺乳动物细胞和斑马鱼中的氧化微环境。EPL-Fc 可以减轻炎症反应。此外，这些高分子可以加速细菌感染的伤口愈合。这项工作提供了一种通过消除细菌、调节氧化微环境和减轻炎症反应来修复细菌感染伤口的通用策略。
