Department of General Surgery, The Fourth Affiliated Hospital, China Medical University, Shenyang, 110032, China.
Department of Radiology, The Fifth Hospital of Xiamen, Xiamen, 361101, China.
Cell Commun Signal. 2022 Oct 18;20(1):161. doi: 10.1186/s12964-022-00968-3.
The existence of multiple endocytic pathways is well known, and their exact biological effects in tumors have been intensively investigated. Endocytosis can affect the connection between tumor cells and determine the fate of tumor cells. Many relationships between endocytosis and tumor cells have been elucidated, but the mechanism of endocytosis between different types of cells in tumors needs to be explored in greater depth. Endocytic receptors sense the environment and are induced by specific ligands to trigger communication between tumor and immune cells. Crosstalk in the tumor microenvironment can occur through direct contact between cell adhesion molecules or indirectly through exosomes. So a better understanding of the endocytic pathways that control cell adhesion molecules and function is expected to lead to new candidates for cancer treatment. In additional, tumor-derived exosomes may changes immune cell function, which may be a key role for tumors to evade immune detection and response. The overall understanding of exosomes through endocytosis is also expected to bring new candidates for therapeutic regulation of tumor immune microenvironment. In this case, endocytic pathways coordinate cell adhesion molecules and exosomes and can be used as targets in the tumor immune microenvironment for cancer treatment. Video Abstract.
多种内吞途径的存在是众所周知的，它们在肿瘤中的确切生物学效应也被深入研究。内吞作用可以影响肿瘤细胞之间的连接，决定肿瘤细胞的命运。已经阐明了内吞作用与肿瘤细胞之间的许多关系，但需要更深入地探讨肿瘤中不同类型细胞之间的内吞作用机制。内吞受体感知环境，并被特定的配体诱导，从而触发肿瘤和免疫细胞之间的通讯。肿瘤微环境中的串扰可以通过细胞黏附分子的直接接触或通过外泌体的间接接触发生。因此，更好地了解控制细胞黏附分子和功能的内吞途径有望为癌症治疗带来新的候选药物。此外，肿瘤衍生的外泌体可能改变免疫细胞的功能，这可能是肿瘤逃避免疫检测和反应的关键作用。通过内吞作用对外泌体的全面了解也有望为肿瘤免疫微环境的治疗调节带来新的候选药物。在这种情况下，内吞途径协调细胞黏附分子和外泌体，并可作为肿瘤免疫微环境中癌症治疗的靶点。视频摘要。
