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通用超声神经调控系统，用于自由活动啮齿类动物的慢性、闭环临床前研究。

General-Purpose Ultrasound Neuromodulation System for Chronic, Closed-Loop Preclinical Studies in Freely Behaving Rodents.

机构信息

School of Electrical Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, 34141, Republic of Korea.

Korea Brain Research Institute (KBRI), Daegu, 41068, Republic of Korea.

出版信息

Adv Sci (Weinh). 2022 Dec;9(34):e2202345. doi: 10.1002/advs.202202345. Epub 2022 Oct 19.

DOI:10.1002/advs.202202345
PMID:36259285
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9731702/
Abstract

Transcranial focused ultrasound stimulation (tFUS) is an effective noninvasive treatment modality for brain disorders with high clinical potential. However, the therapeutic effects of ultrasound neuromodulation are not widely explored due to limitations in preclinical systems. The current preclinical studies are head-fixed, anesthesia-dependent, and acute, limiting clinical translatability. Here, this work reports a general-purpose ultrasound neuromodulation system for chronic, closed-loop preclinical studies in freely behaving rodents. This work uses microelectromechanical systems (MEMS) technology to design and fabricate a small and lightweight transducer capable of artifact-free stimulation and simultaneous neural recording. Using the general-purpose system, it can be observed that state-dependent ultrasound neuromodulation of the prefrontal cortex increases rapid eye movement (REM) sleep and protects spatial working memory to REM sleep deprivation. The system will allow explorative studies in brain disease therapeutics and neuromodulation using ultrasound stimulation for widespread clinical adoption.

摘要

经颅聚焦超声刺激（tFUS）是一种治疗脑部疾病的有效非侵入性方法，具有很高的临床应用潜力。然而，由于临床前系统的限制，超声神经调节的治疗效果尚未得到广泛探索。目前的临床前研究是基于头部固定、依赖麻醉和急性的，限制了临床转化。本研究报告了一种通用的超声神经调节系统，用于在自由活动的啮齿动物中进行慢性、闭环的临床前研究。本研究使用微机电系统（MEMS）技术设计和制造了一种小型、轻便的换能器，能够进行无伪影刺激和同时进行神经记录。使用通用系统，可以观察到前额叶皮层的状态依赖超声神经调节可以增加快速眼动（REM）睡眠并保护空间工作记忆免受 REM 睡眠剥夺。该系统将允许使用超声刺激进行广泛的临床应用，探索针对脑部疾病治疗和神经调节的研究。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b7d/9731702/23774dbe70f6/ADVS-9-2202345-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b7d/9731702/335f911daef3/ADVS-9-2202345-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b7d/9731702/cc6019ce956d/ADVS-9-2202345-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b7d/9731702/34ffda91c394/ADVS-9-2202345-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b7d/9731702/ec0ad3f58747/ADVS-9-2202345-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b7d/9731702/23774dbe70f6/ADVS-9-2202345-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b7d/9731702/335f911daef3/ADVS-9-2202345-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b7d/9731702/cc6019ce956d/ADVS-9-2202345-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b7d/9731702/34ffda91c394/ADVS-9-2202345-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b7d/9731702/ec0ad3f58747/ADVS-9-2202345-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b7d/9731702/23774dbe70f6/ADVS-9-2202345-g002.jpg

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