Zhang Yingxin, Yang Zhengling, Yang Huan, Li Xiuyong, Liu Zhi, Bai Youwei, Qian Guangrong, Wu Han, Li Ji, Guo Yuwen, Yang Shanfei, Chen Lei, Yang Jian, Han Jiuhuai, Ma Shengyin, Yang Jing, Yu Linfei, Shui Runzhi, Jin Xiping, Wang Hongyu, Zhang Fan, Chen Tianhao, Li Xinke, Zong Xiaoying, Liu Li, Fan Jihui, Wang Wei, Zhang Yong, Shi Guangcai, Wang Deguang, Tao Shuman
Department of Nephrology, The Second Hospital of Anhui Medical University, Hefei, China.
Blood Purification Center, No. 2 People's Hospital of Fuyang City, Fuyang, China.
Front Physiol. 2022 Oct 3;13:963914. doi: 10.3389/fphys.2022.963914. eCollection 2022.
Serum magnesium (Mg) levels are associated with insulin resistance, hypertension, lipid abnormalities, and inflammation. However, limited studies have indicated the relationship between Mg and multiple system indexes. The purpose of this study was to investigate the association between Mg and allostatic load (AL) in hemodialysis patients. A cross-sectional survey was conducted on hemodialysis patients from different centers in Anhui Province, China, between January and December 2020. A total of 3,025 hemodialysis patients were recruited. Their clinical data were measured before hemodialysis. Information was collected by an online self-reported questionnaire and medical record. Serum Mg was divided into three groups by tertiles. A score of AL greater than or equal to 3 was defined as high AL. A binary logistic regression model was applied to examine the relationship between serum Mg and AL. A total of 1,222 patients undergoing hemodialysis were included, 60% of whom were males (733/1,222). The mean (standard deviation) age of patients was 55.90 (12.75). The median level of serum Mg was 1.22 mmol/L. The rate of high AL levels was 23.4%. Serum Mg was negatively correlated with body mass index, fasting blood glucose (Glu), and C-reactive protein and positively correlated with high-density lipoprotein, low-density lipoprotein, total cholesterol, diastolic blood pressure (DBP), and serum phosphorus. After adjusting for gender, anxiety, diabetes, family residence, lipid-lowering agents, antihypertensive medications, albumin, and Glu, the binary logistic regression model showed that patients with lower levels of serum Mg were more likely have high AL ( for the T1 group of serum Mg:1.945, 95% : 1.365-2.773, and for the T2 group of serum Mg:1.556, 95% : 1.099-2.201). Our data support the hypothesis that higher serum Mg concentrations may contribute to lower health risk in hemodialysis populations. Further randomized controlled trials and cohort studies are warranted to verify whether Mg supplementation could be part of routine examinations in hemodialysis populations.
血清镁（Mg）水平与胰岛素抵抗、高血压、血脂异常及炎症相关。然而，仅有有限的研究表明镁与多系统指标之间的关系。本研究旨在探讨血液透析患者中镁与应激负荷（AL）之间的关联。2020年1月至12月，对中国安徽省不同中心的血液透析患者进行了一项横断面调查。共招募了3025例血液透析患者。在血液透析前测量他们的临床数据。通过在线自填问卷和病历收集信息。血清镁按三分位数分为三组。AL评分大于或等于3被定义为高AL。应用二元逻辑回归模型来检验血清镁与AL之间的关系。共纳入1222例接受血液透析的患者，其中60%为男性（733/1222）。患者的平均（标准差）年龄为55.90（12.75）岁。血清镁的中位数水平为1.22 mmol/L。高AL水平的发生率为23.4%。血清镁与体重指数、空腹血糖（Glu）和C反应蛋白呈负相关，与高密度脂蛋白、低密度脂蛋白、总胆固醇、舒张压（DBP）和血清磷呈正相关。在调整性别、焦虑、糖尿病、家庭住址、降脂药物、抗高血压药物、白蛋白和Glu后，二元逻辑回归模型显示，血清镁水平较低的患者更有可能具有高AL（血清镁的T1组：1.945，95%可信区间：1.365 - 2.773；血清镁的T2组：1.556，95%可信区间：1.099 - 2.201）。我们的数据支持这样的假设，即较高的血清镁浓度可能有助于降低血液透析人群的健康风险。有必要进行进一步的随机对照试验和队列研究，以验证补充镁是否可以成为血液透析人群常规检查的一部分。
