中华辛醇H-J，三种源自（Desv.）Spring的新木脂素衍生物。
Sinensiols H-J, three new lignan derivatives from (Desv.) Spring.
作者信息
Zhu Qinfeng, Gao Beibei, Chen Qian, Luo Tiantian, Xu Guobo, Liao Shanggao
机构信息
School of Pharmacy, Guizhou Medical University, No. 2 Dongqing Road, Guiyang, 550025, P. R. China.
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, No.132 Lanhei Road, Kunming, 650203, P. R. China.
出版信息
Beilstein J Org Chem. 2022 Oct 7;18:1410-1415. doi: 10.3762/bjoc.18.146. eCollection 2022.
One new lignan sinensiol H () and two new bisnorlignans, sinensiols I and J ( and ), along with three known compounds were isolated from the whole plants of . Their structures were elucidated on the basis of 1D and 2D NMR spectroscopy as well as high-resolution mass spectrometry. The absolute configuration of was established by ECD calculation. Compounds and represent rare examples of naturally occurring 9,9'-bisnorlignans. All the isolated compounds were assayed for their inhibitory effects on LPS-induced nitric oxide production in RAW 264.7 macrophages.
从[植物名称]全草中分离得到一个新的木脂素中华脂素H（）和两个新的双降木脂素，中华脂素I和J（和），以及三个已知化合物。通过一维和二维核磁共振光谱以及高分辨率质谱对它们的结构进行了阐明。通过电子圆二色光谱（ECD）计算确定了的绝对构型。化合物和是天然存在的9,9'-双降木脂素的罕见例子。对所有分离得到的化合物进行了测定，考察它们对RAW 264.7巨噬细胞中脂多糖（LPS）诱导的一氧化氮产生的抑制作用。
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