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原发性硬化性胆管炎:妊娠期肝功能障碍的罕见病因。

Primary sclerosing cholangitis: A rare cause of liver dysfunction in pregnancy.

作者信息

Slade Laura, McKendrick Linda, Grivell Rosalie

机构信息

Flinders Medical Centre, Flinders University, Bedford Park, Australia.

出版信息

Obstet Med. 2022 Sep;15(3):195-197. doi: 10.1177/1753495X21991406. Epub 2021 Mar 9.

Abstract

Primary sclerosing cholangitis is an uncommon condition with few cases reported in pregnancy. We present the case and outcome of a 28-year-old female presenting in her second pregnancy with new onset liver dysfunction, eventually diagnosed with primary sclerosing cholangitis. She went into spontaneous preterm labour and delivered a healthy infant but has subsequently continued to deteriorate and underwent a liver transplant 11 months post-delivery.

摘要

原发性硬化性胆管炎是一种罕见疾病,孕期报道的病例较少。我们报告一例28岁女性病例及其转归,该女性在第二次妊娠时出现新发肝功能障碍,最终被诊断为原发性硬化性胆管炎。她发生了自发性早产并产下一名健康婴儿,但随后病情持续恶化,在产后11个月接受了肝移植。

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Primary sclerosing cholangitis and pregnancy.原发性硬化性胆管炎与妊娠
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本文引用的文献

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ACG Clinical Guideline: Liver Disease and Pregnancy.美国胃肠病学会临床指南:肝病与妊娠
Am J Gastroenterol. 2016 Feb;111(2):176-94; quiz 196. doi: 10.1038/ajg.2015.430. Epub 2016 Feb 2.
5
Pregnancy and liver disease.妊娠与肝脏疾病。
J Hepatol. 2016 Apr;64(4):933-45. doi: 10.1016/j.jhep.2015.11.030. Epub 2015 Nov 30.
6
Abnormal liver function tests in pregnancy.
BMJ. 2013 Oct 25;347:f6055. doi: 10.1136/bmj.f6055.
7
Pregnancy in primary sclerosing cholangitis.原发性硬化性胆管炎患者的妊娠问题。
Gut. 2011 Aug;60(8):1117-21. doi: 10.1136/gut.2010.228924. Epub 2011 Feb 21.
8
Liver disease in pregnancy.妊娠期肝病。
Lancet. 2010 Feb 13;375(9714):594-605. doi: 10.1016/S0140-6736(09)61495-1.

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