Li Xiaopan, Zhang Mo, Chen Yichen, Lv Huihui, Du Yan
Department of Health Management Center, Zhongshan Hospital, Shanghai Medical College of Fudan University, Shanghai, China.
Clinical Research Unit, Obstetrics and Gynecology Hospital, Fudan University, Shanghai, China.
Front Oncol. 2022 Oct 3;12:1003297. doi: 10.3389/fonc.2022.1003297. eCollection 2022.
It is important to assess the burden of ovarian cancer related premature death so as to develop appropriate evidence-based care and improve women's health. This study aimed to characterize the long-term trends in mortality, survival and disease burden of ovarian cancer in Shanghai, China.
Co-morbidities, crude mortality rate (CMR), age-standardised mortality rate by Segi's world standard population (ASMRW), years of life lost (YLL), and survival rates were analysed. Temporal trends for the mortality rates and disease burden were analyzed using the Joinpoint Regression Program. Mortality rate increases by demographic and non-demographic factors were estimated by the decomposition method.
A total of 1088 ovarian cancer as underlying cause of deaths were recorded. CMR and ASMRW were 4.82/10 and 2.32/10 person-years, respectively. The YLL was 16372.96 years, and the YLL rate was 72.46/10 person-years. The YLL rate increased only in the age group of 70-79 years (P = 0.017). The survival rates of ovarian cancer patients did not improve during the ten year period (2005-2015). The top co-morbidities were diseases of the respiratory system, digestive system, and circulatory system. The rates of ovarian cancer deaths caused by non-demographic and demographic factors increased by 21.29% (95%CI: 4.01% to 41.44%, P = 0.018) and 25.23% (95%CI: 14.64% to 36.81%, P < 0.001), respectively.
Population ageing and all cause of death may affect ovarian cancer related deaths in Pudong, Shanghai. The high mortality and the stagnant survival rates suggest the need for more efforts in targeted prevention and treatment of this disease.
评估卵巢癌相关过早死亡的负担对于制定恰当的循证护理措施及改善女性健康状况至关重要。本研究旨在描述中国上海卵巢癌死亡率、生存率及疾病负担的长期趋势。
分析合并症、粗死亡率（CMR）、基于Segi世界标准人口的年龄标准化死亡率（ASMRW）、寿命损失年数（YLL）及生存率。使用Joinpoint回归程序分析死亡率和疾病负担的时间趋势。采用分解法估算人口统计学和非人口统计学因素导致的死亡率上升情况。
共记录了1088例以卵巢癌为根本死因的死亡病例。CMR和ASMRW分别为4.82/10和2.32/10人年。YLL为16372.96年，YLL率为72.46/10人年。YLL率仅在70 - 79岁年龄组有所上升（P = 0.017）。在十年期间（2005 - 2015年），卵巢癌患者的生存率并未提高。最常见的合并症是呼吸系统疾病、消化系统疾病和循环系统疾病。非人口统计学和人口统计学因素导致的卵巢癌死亡率分别上升了21.29%（95%CI：4.01%至41.44%，P = 0.018）和25.23%（95%CI：14.64%至36.81%，P < 0.001）。
人口老龄化和全因死亡可能影响上海浦东新区卵巢癌相关死亡。高死亡率和停滞不前的生存率表明需要在该疾病的针对性预防和治疗方面做出更多努力。
