Department of Health Management Centre, Zhongshan Hospital, Fudan University.
Department of General Practice, Zhongshan Hospital, Fudan University.
Eur J Cancer Prev. 2023 Nov 1;32(6):517-524. doi: 10.1097/CEJ.0000000000000823. Epub 2023 Jul 3.
Studies on the epidemiology of liver metastases (LM)-related mortality are rare. we aimed to describe the burden and trend of liver metastases in Pudong of Shanghai, which could be beneficial to cancer prevention.
We performed a retrospective population-based analysis of cancer mortality data with liver metastases in Shanghai Pudong from 2005 to 2021. Long-term trends in crude mortality rates (CMRs), age-standardized mortality rates worldwide, and rate of years of life lost (YLL) were analyzed by the Join-point regression model. In addition, we evaluate the impact of the demographic and nondemographic factors on the mortality of disease by the decomposition method.
Cancer with liver metastases accounted for 26.68% of all metastases. The CMR and age-standardized mortality rates by Segi's world population (ASMRW) of cancer with liver metastases were 15.12/105 person-years and 6.33/105 person-years, respectively. The YLL from cancer with liver metastases was 84 959.87 years, with the age group of 60-69 years having the highest YLL of 26 956.40 years. The top three cancer types in liver metastases are colorectal, gastric, and pancreatic cancer. The long-term trend of ASMRW significantly decreased by 2.31% per year ( P <0.05). The ASMRW and YLL rates of those over 45 decreased year by year. Particularly striking was the 70-79 age group. Although the overall mortality of cancer with liver metastases decreased, there was still a significant upward trend toward an increased mortality rate caused by cancer with liver metastases in aging patients.
Liver metastases were a common site of metastases in patients with cancers originating from the digestive system. The disease burden caused by cancer with liver metastases provides valuable evidence for cancer management.
关于肝转移（LM）相关死亡率的流行病学研究较为罕见。我们旨在描述上海浦东新区肝转移的负担和趋势，这对癌症预防可能有益。
我们对 2005 年至 2021 年上海浦东新区癌症死亡率数据中肝转移的人群进行了回顾性分析。使用 Joinpoint 回归模型分析粗死亡率（CMR）、世界人口年龄标准化死亡率（ASMRW）和寿命损失年（YLL）的长期趋势。此外，我们还通过分解方法评估人口和非人口因素对疾病死亡率的影响。
癌症肝转移占所有转移的 26.68%。CMR 和 ASMRW 分别为 15.12/105 人年和 6.33/105 人年。肝转移导致的 YLL 为 84959.87 年，60-69 岁年龄组的 YLL 最高，为 26956.40 年。肝转移中排名前三的癌症类型是结直肠癌、胃癌和胰腺癌。ASMRW 的长期趋势呈每年下降 2.31%（P<0.05）。45 岁以上人群的 ASMRW 和 YLL 率逐年下降。70-79 岁年龄组尤为明显。尽管肝转移相关癌症的总体死亡率有所下降，但由于老年患者肝转移导致的死亡率仍呈显著上升趋势。
肝转移是消化系统来源癌症患者常见的转移部位。肝转移相关癌症造成的疾病负担为癌症管理提供了有价值的证据。
