Hass Holger G, Herzberger Andrea, Wöckel Achim, Stepien Jürgen
Abt. Onkologie, Klinik Gais, Gais, Switzerland.
Dep. Innere Medizin, Klinik Gais, Gais, Switzerland.
Oncol Res Treat. 2022;45(12):736-743. doi: 10.1159/000526704. Epub 2022 Oct 20.
Male breast cancer (MBC) is a rare malignancy that accounts for less than 1% of all cancers in men and less than 1% of all breast cancers worldwide. Understandably, due to the low incidence of this rare cancer, there is a lack of prospective clinical data. The aim of this retrospective study was the analysis of therapy-induced toxicities as well as the assessment of psychological distress in the affected men during oncological inpatient rehabilitation.
Fifty-one MBC patients were evaluated for the presence of treatment-induced side effects, toxicities, and psychological distress (using German version of the 11-stage NCCN distress thermometer; cut-off ≥5) during oncological indoor rehabilitation. The collected data were checked for correlation with sociodemographic and clinical factors (SPSS 22).
The mean age was 62.0 ± 10.6 years, in 96% a hormone-dependent breast tumor (ER+), and in over 75%, overweight or obesity (BMI >25/>30) was diagnosed. Most reported side effects included weakness/fatigue (74.5%), arthralgia after surgery/chemotherapy (43.1%), chemotherapy-induced polyneuropathy (36.3%), and/or lymphedema (13.7%). Psychological distress was detected in 24 cases (47.0%; ≥5), in 13 cases even with significantly high levels (25.5%; ≥7). There was no correlation between psychological distress and clinical factors such as age, performed treatment (e.g., chemotherapy), or therapy-induced side effects (e.g., lymphedema) in our small collective.
Psychological distress and somatic side effects are common in MBC. These data demonstrate the importance of routine screening for psychological distress and the high need for psycho-oncological therapy (regardless of gender) in multimodal oncological rehabilitation.
男性乳腺癌（MBC）是一种罕见的恶性肿瘤，在男性所有癌症中占比不到1%，在全球所有乳腺癌中占比也不到1%。可以理解的是，由于这种罕见癌症的发病率较低，缺乏前瞻性临床数据。这项回顾性研究的目的是分析治疗引起的毒性反应以及评估肿瘤住院康复期间受影响男性的心理困扰。
在肿瘤室内康复期间，对51例MBC患者进行评估，以确定是否存在治疗引起的副作用、毒性反应和心理困扰（使用德语版的11阶段NCCN困扰温度计；临界值≥5）。检查收集的数据与社会人口统计学和临床因素的相关性（SPSS 22）。
平均年龄为62.0±10.6岁，96%为激素依赖性乳腺肿瘤（ER+），超过75%被诊断为超重或肥胖（BMI>25/>30）。大多数报告的副作用包括虚弱/疲劳（74.5%）、手术/化疗后关节痛（43.1%）、化疗引起的多发性神经病（36.3%）和/或淋巴水肿（13.7%）。24例（47.0%；≥5）检测到心理困扰，13例甚至有显著高水平（25.5%；≥7）。在我们这个小群体中，心理困扰与年龄、所进行的治疗（如化疗）或治疗引起的副作用（如淋巴水肿）等临床因素之间没有相关性。
心理困扰和躯体副作用在MBC中很常见。这些数据表明在多模式肿瘤康复中常规筛查心理困扰的重要性以及心理肿瘤治疗（不分性别）的高度必要性。
