Boston Children's Hospital, 300 Longwood Avenue, Fegan 6, Boston, MA 02115, USA.
EH - Exposure Epidemiology and Risk Program, Harvard TH Chan School of Public Health, Landmark Center West, Room 420401 Park Dr, Boston, MA 02215, USA.
Immunol Allergy Clin North Am. 2022 Nov;42(4):743-760. doi: 10.1016/j.iac.2022.05.005. Epub 2022 Sep 24.
The school is a microenvironment well-known to host many indoor allergens and pollutants, with a strong association between school allergen exposure and childhood asthma morbidity. Despite advances in therapies, asthma continues to be one of the most common chronic conditions among children, associated with significant morbidity, health care utilization, and productivity loss. Asthma prevalence is also disproportionately high among children in minority communities. This review will focus on environmental exposures associated with asthma morbidity (cockroach, mouse, cat and dog, dust mite, fungus, air pollution). This review will also discuss recent school-based interventions to improve allergy morbidity among school-aged children. Understanding the multifaceted environmental factors which may contribute to asthma pathogenesis is necessary to help guide potential school-based interventions.
学校是一个众所周知的微环境，容纳了许多室内过敏原和污染物，学校过敏原暴露与儿童哮喘发病率之间存在很强的关联。尽管治疗方法有所进步，但哮喘仍然是儿童中最常见的慢性疾病之一，与显著的发病率、医疗保健利用和生产力损失相关。哮喘在少数族裔社区的儿童中也不成比例地高发。本综述将重点关注与哮喘发病率相关的环境暴露（蟑螂、老鼠、猫和狗、尘螨、真菌、空气污染）。本综述还将讨论最近基于学校的干预措施，以改善学龄儿童的过敏发病率。了解可能导致哮喘发病机制的多方面环境因素对于指导潜在的基于学校的干预措施是必要的。
