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肌少症与巴西社区居住老年人的死亡风险。

Sarcopenia and mortality risk in community-dwelling Brazilian older adults.

机构信息

Postgraduate Program in Health Sciences, Medical School, Federal University of Goiás (UFG), Goiania, Brazil.

Postgraduate Program in Nursing, Faculty of Nursing, Federal University of Goiás (UFG), Goiania, Brazil.

出版信息

Sci Rep. 2022 Oct 20;12(1):17531. doi: 10.1038/s41598-022-22153-9.

Abstract

We estimated the impact of sarcopenia parameters on mortality risk and assessed its prevalence and associated factors in the older adults according to the European Working Group on Sarcopenia in Older People's 2010 (EWGSOP1) and 2018 (EWGSOP2) criteria. This was a 10-year follow-up cohort study. Low muscle mass (MM) was defined as low skeletal muscle mass index (SMI) using dual-energy X-ray absorptiometry (DXA), and low calf circumference (CC). Cox regression and the Kaplan-Meier method were performed. The prevalence of sarcopenia and associated factors were influenced by the MM measurement method and diagnostic criteria used [6.8% (SMI and EWGSOP2), 12.8% (CC and EWGSOP2; and SMI and EWGSOP1) and 17.4% (CC and EWGSOP1)]. While a low BMI was associated with sarcopenia regardless of the sarcopenia definitions, diabetes, and high TGs were associated with sarcopenia only when using the EWGSOP1 criteria. Low SMI increased mortality risk (EWGSOP1: HR = 2.01, 95% CI 1.03-3.92; EWGSOP2: HR = 2.07, 95% CI 1.05-4.06). The prevalence of sarcopenia was higher according to EWGSOP1 than EWGSOP2. A low BMI, diabetes, and high TGs were associated with sarcopenia. A low SMI doubled the risk of mortality in community-dwelling older adults.

摘要

我们根据欧洲老年人肌少症工作组 2010 年(EWGSOP1)和 2018 年(EWGSOP2)标准,评估了肌少症参数对死亡风险的影响,并评估了其在老年人中的患病率和相关因素。这是一项为期 10 年的随访队列研究。低肌肉量(MM)的定义为使用双能 X 射线吸收法(DXA)测量的低骨骼肌指数(SMI)和低小腿围(CC)。采用 Cox 回归和 Kaplan-Meier 方法进行分析。肌少症的患病率和相关因素受 MM 测量方法和使用的诊断标准影响[6.8%(SMI 和 EWGSOP2)、12.8%(CC 和 EWGSOP2;和 SMI 和 EWGSOP1)和 17.4%(CC 和 EWGSOP1)]。虽然无论采用何种肌少症定义,低 BMI 均与肌少症相关,但只有在使用 EWGSOP1 标准时,糖尿病和高 TG 才与肌少症相关。低 SMI 增加了死亡风险(EWGSOP1:HR=2.01,95%CI 1.03-3.92;EWGSOP2:HR=2.07,95%CI 1.05-4.06)。根据 EWGSOP1,肌少症的患病率高于 EWGSOP2。低 BMI、糖尿病和高 TG 与肌少症相关。低 SMI 使社区居住的老年人的死亡风险增加了一倍。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/71ba/9585028/19b08c1e33fc/41598_2022_22153_Fig1_HTML.jpg

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