Yu Liqiong, Li Shiling, Pu Lili, Yang Chunhong, Shi Qian, Zhao Qi, Meniga Shengbu, Liu Yue, Zhang Yi, Lai Xianrong
State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
State Key Laboratory of Southwestern Chinese Medicine Resources, School of Ethnic Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Front Pharmacol. 2022 Oct 4;13:938915. doi: 10.3389/fphar.2022.938915. eCollection 2022.
Rheumatoid arthritis (RA) is a severe inflammatory autoimmune disease characterized by the failed spontaneous resolution of inflammation. The induction of immune regulation and resolution of inflammatory pathways are effective in alleviating inflammation in RA. As the oldest medical system in the world, traditional Tibetan medicine (TTM) has a long history of preventing and treating RA. This review provides a comprehensive overview of medicinal plants with anti-RA activity in the TTM system, using classic books of Tibetan medicine, modern research literature, and drug standards. A total of 27 species have been found to be effective in treating RA, including (Lour.) Merr., Retz., (C. B. Clarke) Hock.), and Busch. Alkaloids, flavonoids, polyphenols, and terpenoids have turned out to be the major bioactive components for RA treatment. The inhibition of pro-inflammatory cytokine expression by mediating the NF-κB, MAPK, and JAK/STAT pathways is the core mechanism in RA treatment. In conclusion, this review provides key information and research perspectives for further research on the anti-RA effects of TTM.
类风湿性关节炎（RA）是一种严重的炎症性自身免疫性疾病，其特征为炎症无法自发消退。诱导免疫调节和解决炎症途径对减轻RA炎症有效。作为世界上最古老的医学体系，传统藏医学（TTM）在预防和治疗RA方面有着悠久的历史。本综述利用藏医经典书籍、现代研究文献和药品标准，全面概述了藏医学体系中具有抗RA活性的药用植物。共发现27种植物对治疗RA有效，包括（罗勒）梅里尔、雷茨、（C.B.克拉克）霍克和布施。生物碱、黄酮类化合物、多酚和萜类化合物已被证明是治疗RA的主要生物活性成分。通过介导NF-κB、MAPK和JAK/STAT途径抑制促炎细胞因子表达是RA治疗的核心机制。总之，本综述为进一步研究藏医学的抗RA作用提供了关键信息和研究视角。
