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外泌体微小RNA在心血管疾病诊断和治疗中作用的研究进展

Progress in research on the role of exosomal miRNAs in the diagnosis and treatment of cardiovascular diseases.

作者信息

Xu Jinyu, Wang Weitie, Wang Yong, Zhu Zhicheng, Li Dan, Wang Tiance, Liu Kexiang

机构信息

Department of Cardiovascular Surgery, The Second Hospital of Jilin University, Changchun, China.

出版信息

Front Genet. 2022 Oct 4;13:929231. doi: 10.3389/fgene.2022.929231. eCollection 2022.

DOI:10.3389/fgene.2022.929231
PMID:36267409
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9577319/
Abstract

Cardiovascular diseases are the most common diseases threatening the health of the elderly, and the incidence and mortality rates associated with cardiovascular diseases remain high and are increasing gradually. Studies on the treatment and prevention of cardiovascular diseases are underway. Currently, several research groups are studying the role of exosomes and biomolecules incorporated by exosomes in the prevention, diagnosis, and treatment of clinical diseases, including cardiovascular diseases. Now, based on the results of published studies, this review discusses the characteristics, separation, extraction, and identification of exosomes, specifically the role of exosomal miRNAs in atherosclerosis, myocardial injury and infarction, heart failure, aortic dissection, myocardial fibrosis, ischemic reperfusion, atrial fibrillation, and other diseases. We believe that the observations noted in this article will aid in the prevention, diagnosis, and treatment of cardiovascular diseases.

摘要

心血管疾病是威胁老年人健康最常见的疾病，且心血管疾病的发病率和死亡率居高不下，并呈逐渐上升趋势。目前正在开展心血管疾病治疗与预防方面的研究。当前，有几个研究小组正在研究外泌体以及外泌体所包含的生物分子在包括心血管疾病在内的临床疾病的预防、诊断和治疗中的作用。现在，基于已发表研究的结果，本综述讨论了外泌体的特征、分离、提取和鉴定，特别是外泌体微小RNA在动脉粥样硬化、心肌损伤与梗死、心力衰竭、主动脉夹层、心肌纤维化、缺血再灌注、心房颤动及其他疾病中的作用。我们认为本文所提及的观察结果将有助于心血管疾病的预防、诊断和治疗。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/23a6/9577319/77483d1fdf76/fgene-13-929231-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/23a6/9577319/b02f02bb51e3/fgene-13-929231-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/23a6/9577319/bd5697e37300/fgene-13-929231-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/23a6/9577319/1aa5262f0156/fgene-13-929231-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/23a6/9577319/7aeb7c956202/fgene-13-929231-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/23a6/9577319/77483d1fdf76/fgene-13-929231-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/23a6/9577319/b02f02bb51e3/fgene-13-929231-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/23a6/9577319/bd5697e37300/fgene-13-929231-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/23a6/9577319/1aa5262f0156/fgene-13-929231-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/23a6/9577319/7aeb7c956202/fgene-13-929231-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/23a6/9577319/77483d1fdf76/fgene-13-929231-g005.jpg

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The Role of Telocytes and Telocyte-Derived Exosomes in the Development of Thoracic Aortic Aneurysm.间质细胞及其衍生的外泌体在胸主动脉瘤发展中的作用。
Int J Mol Sci. 2022 Apr 25;23(9):4730. doi: 10.3390/ijms23094730.
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Minimally invasive delivery of a hydrogel-based exosome patch to prevent heart failure.水凝胶基外泌体贴剂微创递送预防心力衰竭。
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Exosome-Based Treatment for Atherosclerosis.基于外泌体的动脉粥样硬化治疗。
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Blockade of Exosome Release Suppresses Atrial Fibrillation by Alleviating Atrial Fibrosis in Canines With Prolonged Atrial Pacing.抑制外泌体释放通过减轻长期心房起搏犬的心房纤维化来抑制心房颤动。
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