College of Physical Education, Yangzhou University, Yangzhou, China.
Front Endocrinol (Lausanne). 2022 Oct 4;13:989135. doi: 10.3389/fendo.2022.989135. eCollection 2022.
The physiological functions of organs are intercommunicated occurring through secreted molecules. That exercise can improve the physiological function of organs or tissues is believed by secreting myokines from muscle to target remote organs. However, the underlying mechanism how exercise regulates the inter-organ communications remains incompletely understood yet. A recently identified myokine-irisin, primarily found in muscle and adipose and subsequently extending to bone, heart, liver and brain, provides a new molecular evidence for the inter-organ communications. It is secreted under the regulation of exercise and mediates the intercommunications between exercise and organs. To best our understanding of the regulatory mechanism, this review discusses the recent evidence involving the potential molecular pathways of the inter-organ communications, and the interactions between signalings and irisin in regulating the impact of exercise on organ functions are also discussed.
器官的生理功能是通过分泌分子相互沟通的。人们相信，运动可以通过肌肉分泌肌肉因子来改善器官或组织的生理功能，从而作用于远程器官。然而，运动如何调节器官间通讯的潜在机制尚不完全清楚。最近发现的一种肌肉因子——鸢尾素，主要存在于肌肉和脂肪组织中，随后也存在于骨骼、心脏、肝脏和大脑中，为器官间通讯提供了新的分子证据。它在运动的调节下分泌，并介导运动与器官之间的相互通讯。为了更好地理解调节机制，本综述讨论了最近涉及器官间通讯潜在分子途径的证据，以及信号和鸢尾素在调节运动对器官功能影响方面的相互作用。
