Plácido Ana I, Azevedo Daniela, Herdeiro Maria Teresa, Morgado Manuel, Roque Fátima
Biotechnology Research, Innovation and Design for Health Products (BRIDGES), Research Laboratory on Epidemiology and Population Health, Polytechnic of Guarda Av. Dr. Francisco Sá Carneiro 50, 6300-559 Guarda, Portugal.
Department of Medical Sciences, Institute of Biomedicine (iBiMED), University of Aveiro, 3810-193 Aveiro, Portugal.
Epidemiologia (Basel). 2025 Jan 8;6(1):1. doi: 10.3390/epidemiologia6010001.
Irisin is a protein resulting from a proteolytic cleavage of fibronectin type III domain-containing protein 5 (FND5). The ability of irisin to modulate adipocyte and control glucose metabolism in human metabolic diseases gave rise to the hypothesis that irisin could have a pivotal role in aging-related diseases. Although in animal models, increased levels of irisin have been positively associated with better health outcomes, in humans, its role remains controversial. To provide an overview of the main finding on irisin in older adults, a comprehensive search was performed through the MEDLINE-PubMed, Web of Science, Scopus, and Cochrane databases for studies conducted in older adults (≥60 years) published since 2012. After grouping and analyzing the articles based on diseases associated with older adults, the main conclusion of this narrative review is that the included studies did not yield consistent evidence regarding the association between irisin and health or disease in older adults. Further studies are necessary to clarify the effective role of this protein in promoting health and longevity.
鸢尾素是一种由含III型纤连蛋白结构域蛋白5（FND5）经蛋白水解切割产生的蛋白质。鸢尾素在人类代谢疾病中调节脂肪细胞和控制葡萄糖代谢的能力引发了这样一种假说，即鸢尾素可能在与衰老相关的疾病中起关键作用。尽管在动物模型中，鸢尾素水平升高与更好的健康结果呈正相关，但在人类中，其作用仍存在争议。为了概述关于老年人鸢尾素的主要研究结果，我们通过MEDLINE - PubMed、科学网、Scopus和Cochrane数据库，对自2012年以来针对老年人（≥60岁）开展的研究进行了全面检索。在根据与老年人相关的疾病对文章进行分组和分析后，本叙述性综述的主要结论是，纳入的研究并未就鸢尾素与老年人健康或疾病之间的关联得出一致的证据。有必要进行进一步的研究，以阐明这种蛋白质在促进健康和长寿方面的有效作用。
