Division of Biotherapy, Cancer Center, West China Hospital, Cancer Center, Sichuan University, Chengdu, China.
Head & Neck Oncology Ward, Cancer Center, West China Hospital, Cancer Center, Sichuan University, Chengdu, China.
Front Immunol. 2022 Oct 4;13:1013506. doi: 10.3389/fimmu.2022.1013506. eCollection 2022.
Ovarian cancer is currently one of the most common malignant tumors in females with poor survival rates around the world, killing about 200,000 women each year. Although great progress has been made in treatment, most patients receiving first-line therapy experience tumor recurrence. The tumor microenvironment plays an important role in regulating the progression and prognosis of ovarian cancer. Cancer-associated mesothelial cells are the main cell population in the tumor microenvironment, which affect the progression, prognosis and chemical resistance of ovarian cancer. Cancer-associated mesothelial cells can also interact with other microenvironmental components, such as exosomes, macrophages, and adipocytes. Some studies have developed drugs targeting cancer-associated mesothelial cells in ovarian cancer to evaluate the therapeutic efficiency. In this review we highlighted the key role of cancer-associated mesothelial cells in the progression and prognosis of ovarian cancer. We also described the progress of cancer-associated mesothelial cells targeted therapy for ovarian cancer. Continued insight into the role of cancer-associated mesothelial cells in ovarian cancer will potentially contribute to the development of new and effective therapeutic regiments.
卵巢癌是目前女性中最常见的恶性肿瘤之一，全球范围内生存率较差，每年约有 20 万名女性因此死亡。尽管在治疗方面取得了很大进展，但大多数接受一线治疗的患者都会经历肿瘤复发。肿瘤微环境在调节卵巢癌的进展和预后方面起着重要作用。癌相关间皮细胞是肿瘤微环境中的主要细胞群体，它们影响卵巢癌的进展、预后和化疗耐药性。癌相关间皮细胞还可以与其他微环境成分相互作用，如外泌体、巨噬细胞和脂肪细胞。一些研究已经开发出针对卵巢癌中癌相关间皮细胞的药物，以评估其治疗效果。在这篇综述中，我们强调了癌相关间皮细胞在卵巢癌进展和预后中的关键作用。我们还描述了针对卵巢癌癌相关间皮细胞的靶向治疗的进展。对癌相关间皮细胞在卵巢癌中的作用的进一步深入了解，可能有助于开发新的、有效的治疗方案。
