Khalid Subaina Naeem, Amir Najah Zari, Khan Zeest Ali, Khan Amin Moazzam, Khalid Rehab Naeem, Ali Muhammad Hamza, Ur-Rehman Ibad, Abbasher Hussien Mohamed Ahmed Khabab, Ullah Irfan
Shifa College of Medicine, Shifa Tameer e Millat University, Islamabad, Pakistan.
Agha Khan University, Karachi, Pakistan.
Ann Med Surg (Lond). 2022 Sep 22;82:104738. doi: 10.1016/j.amsu.2022.104738. eCollection 2022 Oct.
Post-transplant lymphoproliferative disorders(PTLD) include a mix of rare yet life endangering complications.
Here, we report a case of a 63-year-old man who was the victim of post-transplant lymphoproliferative disorder (Hodgkin's lymphoma). The patient was initially diagnosed with multiple myeloma, for which chemotherapy and the autologous stem cell transplant was carried out. Post transplant patient was stable but on a follow up visit 6 months after the transplant he presented with generalized lymphadenopathy.His subsequent workup was done including a biopsy of cervical lymph node, which revealed Classical Hodgkin's lymphoma (post-transplant lymphoproliferative disorder (PTLD)) of mixed cellularity type.The patient was started on chemotherapy and received a total of 4 cycles of Chemotherapy (ABVD) before his condition started deteriorating as chemotherapy was poorly tolerated leading to Bleomycin toxicity. The patient regrettably passed away due to an NSTEMI.
移植后淋巴细胞增殖性疾病（PTLD）包括一系列罕见但危及生命的并发症。
在此，我们报告一例63岁男性患者，他是移植后淋巴细胞增殖性疾病（霍奇金淋巴瘤）的受害者。该患者最初被诊断为多发性骨髓瘤，为此接受了化疗和自体干细胞移植。移植后患者情况稳定，但在移植后6个月的一次随访中，他出现了全身淋巴结肿大。随后对其进行了包括颈部淋巴结活检在内的检查，结果显示为混合细胞型经典霍奇金淋巴瘤（移植后淋巴细胞增殖性疾病（PTLD））。患者开始接受化疗，在病情开始恶化之前共接受了4个周期的化疗（ABVD方案）, 因为化疗耐受性差导致博来霉素毒性。遗憾的是，该患者因非ST段抬高型心肌梗死去世。
