Department of Endocrinology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, China.
Guang Dong Clinical Research Center for Metabolic Diseases.
Postgrad Med. 2023 Apr;135(3):290-295. doi: 10.1080/00325481.2022.2139485. Epub 2022 Oct 28.
Sleep plays a critical role in maintaining human health. This study aimed to explore the association between sleep status and thyroid nodules.
A total of 2414 individuals aged 18 or older with euthyroidism were enrolled in this community-based survey. Sleep status was self-reported. Thyroid ultrasonography was performed to measure nodules. Multiple logistic analyses were applied to adjust for confounding factors.
The percentages of thyroid nodules among individuals who slept <5 hours, 5-8 hours, and >8 hours per night were 57.79% (115/199), 44.19% (833/1885) and 42.73% (141/330), respectively (p = 0.001). Individuals who slept <5 hours per night had a significantly higher percentage of thyroid nodules than those who slept 5-8 hours per night (57.79% vs. 44.19%, p = 0.001) or >8 hours per night (57.79% vs. 42.73%, P < 0.001). However, no similar result was shown between individuals who slept >8 hours and 5-8 hours per night (42.73% vs. 44.19%, p = 0.621). Multiple logistic analysis showed that a sleep duration of <5 hours per night was significantly associated with thyroid nodules (odds ratio (OR) 1.643, 95% confidence interval (CI) 1.084-2.490, p = 0.019) when compared to a sleep duration of >8 hours per night. However, a sleep duration of <5 hours per night was not associated with thyroid nodules compared to a sleep duration of 5-8 hours (OR 1.294, 95% CI 0.918-1.824, p = 0.141). Similarly, no significant differences were seen among sleep duration per day, time of falling asleep, habit of daytime napping or thyroid nodules in multiple logistic analyses (all p > 0.05).
Short nighttime sleep duration was associated with thyroid nodules in our community-based population. Screening for thyroid nodules among these individuals is recommended.
睡眠对维持人类健康起着至关重要的作用。本研究旨在探讨睡眠状况与甲状腺结节之间的关系。
本社区为基础的调查共纳入 2414 名年龄在 18 岁及以上的甲状腺功能正常个体。睡眠状况由自我报告。通过甲状腺超声检查测量结节。应用多因素逻辑分析调整混杂因素。
每晚睡眠<5 小时、5-8 小时和>8 小时的个体中甲状腺结节的百分比分别为 57.79%（115/199）、44.19%（833/1885）和 42.73%（141/330）（p=0.001）。每晚睡眠<5 小时的个体甲状腺结节的百分比明显高于每晚睡眠 5-8 小时（57.79% vs. 44.19%，p=0.001）或>8 小时（57.79% vs. 42.73%，P<0.001）。然而，每晚睡眠>8 小时和 5-8 小时的个体之间没有显示出类似的结果（42.73% vs. 44.19%，p=0.621）。多因素逻辑分析显示，与每晚睡眠>8 小时相比，每晚睡眠<5 小时与甲状腺结节显著相关（比值比[OR] 1.643，95%置信区间[CI] 1.084-2.490，p=0.019）。然而，与每晚睡眠 5-8 小时相比，每晚睡眠<5 小时与甲状腺结节无关（OR 1.294，95%CI 0.918-1.824，p=0.141）。同样，在多因素逻辑分析中，每天睡眠时间、入睡时间、白天小睡习惯或甲状腺结节之间也没有显著差异（所有 p>0.05）。
在我们的社区人群中，夜间睡眠时间短与甲状腺结节有关。建议对这些个体进行甲状腺结节筛查。
