College of Otolaryngology Head and Neck Surgery, Chinese PLA General Hospital, 28 Fuxing Road, Beijing, 100853, China.
National Clinical Research Center for Otolaryngologic Diseases, Beijing, 100853, China.
BMC Cancer. 2024 May 17;24(1):605. doi: 10.1186/s12885-024-12376-6.
This study was to explore the causal associations of sleep traits including sleep duration, snoring, chronotype, sleep disorders, getting up in the morning, sleeplessness/insomnia and nap during day with the risk of thyroid cancer based on Mendelian randomization (MR) analysis.
Summary single nucleotide polymorphism (SNP)-phenotype association data were obtained from published genome-wide association studies (GWASs) using the FinnGen and UK Biobank databases. A series of screening processes were performed to select qualified SNPs strongly related to exposure. We applied the inverse variance weighted (IVW), the Mendelian Randomization robust adjusted profile score (MR-RAPS), the Mendelian randomization pleiotropy residual sum and outlier (MR-PRESSO), and the Weighted Median to estimate the causal links between sleep traits and the risk of thyroid cancer. Odds ratio (OR) and 95% confidence interval (CI) were calculated.
The IVW results showed that getting up in the morning (OR = 0.055, 95%CI: 0.004-0.741) and napping during day (OR = 0.031, 95%CI: 0.002-0.462) were associated with decreased risk of thyroid cancer in the Italian population. A 1.30-h decrease of sleep duration was associated with 7.307-fold of thyroid cancer risk in the Finnish population (OR = 7.307, 95%CI: 1.642-32.519). Cronotype could decrease the risk of thyroid cancer in the Finnish population (OR = 0.282, 95%CI: 0.085-0.939). Sleep disorders increased the risk of thyroid cancer in the Finnish population (OR = 2.298, 95%CI: 1.194-4.422). The combined results revealed that sleep duration was correlated with increased risk of thyroid cancer (OR = 5.600, 95%CI: 1.458-21.486).
Decreased sleep duration was associated with increased risk of thyroid cancer, which indicated the importance of adequate sleep for the prevention of thyroid cancer.
本研究旨在通过孟德尔随机化（MR）分析，探讨睡眠特征（包括睡眠时间、打鼾、昼夜型、睡眠障碍、早起、白天失眠/失眠和午睡）与甲状腺癌风险的因果关系。
使用 FinnGen 和 UK Biobank 数据库中的已发表全基因组关联研究（GWAS）汇总单核苷酸多态性（SNP）-表型关联数据。通过一系列筛选过程，选择与暴露有强关联的合格 SNP。我们应用逆方差加权（IVW）、孟德尔随机化稳健调整特征评分（MR-RAPS）、孟德尔随机化多效残余和异常值（MR-PRESSO）和加权中位数来估计睡眠特征与甲状腺癌风险之间的因果关系。计算比值比（OR）和 95%置信区间（CI）。
IVW 结果表明，在意大利人群中，早起（OR=0.055，95%CI：0.004-0.741）和白天午睡（OR=0.031，95%CI：0.002-0.462）与甲状腺癌风险降低相关。在芬兰人群中，睡眠时间减少 1.30 小时与甲状腺癌风险增加 7.307 倍相关（OR=7.307，95%CI：1.642-32.519）。昼夜型可降低芬兰人群患甲状腺癌的风险（OR=0.282，95%CI：0.085-0.939）。睡眠障碍增加了芬兰人群患甲状腺癌的风险（OR=2.298，95%CI：1.194-4.422）。综合结果表明，睡眠时间与甲状腺癌风险增加相关（OR=5.600，95%CI：1.458-21.486）。
睡眠时间减少与甲状腺癌风险增加相关，这表明充足的睡眠对于预防甲状腺癌的重要性。
