Département de Neurologie, Centre Mémoire Ressource et Recherche (CMRR), CHU de Nantes, Nantes, France.
Direction de la recherche, Plateforme de Méthodologie et Biostatistique, CHU de Nantes, Nantes, France.
J Clin Exp Neuropsychol. 2022 Sep;44(7):514-531. doi: 10.1080/13803395.2022.2133088.
We present the preliminary study of the 42-item Semantic Memory Test (SMT-42), a test developed to distinguish semantic variant primary progressive aphasia (svPPA) from the other variants: logopenic (lPPA) and nonfluent/agrammatic (naPPA). The test requires the patient to retrieve the conceptual features of items belonging to different lexical categories.
In the first study, we administered the French version of the SMT-42 to a population of healthy subjects and to patients with svPPA matched to a subgroup of the healthy subjects. In the second study, we administered the SMT-42 to four groups of patients (with svPPA, lPPA, naPPA and Alzheimer's disease [AD], respectively) to study its capacity to differentiate patients suffering from svPPA from the other patients.
In the first study, 109 healthy subjects were included, 15 of whom were paired with 15 subjects presenting with svPPA. In the second study, designed to compare groups presenting a primary progressive aphasia variant and AD, 12 subjects with svPPA, 6 with naPPA and 9 with lPPA were included, along with 21 subjects with AD. The subjects presenting a semantic deficit were clearly distinguished from the others by their results on the SMT-42 (svPPA: mean = 30.0 (5.9); lPPA: mean = 37.8 (3.3), d = 1.5, p = 0.002; naPPA: mean = 39.8 (1.9), d = 1.89, p = 0.001; AD: mean = 38.5 (2.4), d = 1.63, p < 0.001); (svPPA: median = 31; lPPA: median = 38, U = 9, p = 0.002; naPPA: median = 40.5, U = 1.5, p = 0.001; AD: median = 39, U = 13.5, p < 0.001).
The SMT-42 is simple, rapidly administered (3 minutes on average), easily scored and has good sensitivity, and it appears to be an effective tool for semantic screening in routine clinical practice.
我们呈现了 42 项语义记忆测试（SMT-42）的初步研究结果，该测试旨在区分语义变异型原发性进行性失语症（svPPA）与其他变体：失读型（lPPA）和非流利/语法障碍型（naPPA）。该测试要求患者检索属于不同词汇类别的项目的概念特征。
在第一项研究中，我们向健康受试者和与健康受试者相匹配的 svPPA 亚组患者施用法语版 SMT-42。在第二项研究中，我们向四个患者组（svPPA、lPPA、naPPA 和阿尔茨海默病 [AD]）施用 SMT-42，以研究其区分 svPPA 患者与其他患者的能力。
在第一项研究中，纳入了 109 名健康受试者，其中 15 名与 15 名患有 svPPA 的受试者配对。在第二项研究中，为了比较表现出原发性进行性失语症变体和 AD 的组，纳入了 12 名 svPPA 患者、6 名 naPPA 患者和 9 名 lPPA 患者，以及 21 名 AD 患者。语义缺陷患者在 SMT-42 上的表现明显与其他患者区分开来（svPPA：均值=30.0（5.9）；lPPA：均值=37.8（3.3），d=1.5，p=0.002；naPPA：均值=39.8（1.9），d=1.89，p=0.001；AD：均值=38.5（2.4），d=1.63，p<0.001）；（svPPA：中位数=31；lPPA：中位数=38，U=9，p=0.002；naPPA：中位数=40.5，U=1.5，p=0.001；AD：中位数=39，U=13.5，p<0.001）。
SMT-42 简单、快速（平均 3 分钟）施测、易于评分，且具有良好的敏感性，似乎是临床常规中进行语义筛查的有效工具。
