Hu Ruimin, Yang Yang, Song Guojing, Zhao Fuhan, Chen Saipeng, Zhou Zhansong, Zheng Jun, Shen Wenhao
Department of Urology, Southwest Hospital, Army Medical University (Third Military Medical University), Chongqing, China.
Front Bioeng Biotechnol. 2022 Oct 6;10:1021385. doi: 10.3389/fbioe.2022.1021385. eCollection 2022.
Chronic bacterial prostatitis usually occurs in men and seriously affects the quality of life of patients. The efficacy of chronic bacterial prostatitis treatment is limited by the difficulty for free drugs (e.g., antibiotics) to penetrate the prostate epithelium and target inflammatory tissues. The advent of nanotechnology offers the possibility to address this issue, such as the development of targeted nanoparticle delivery strategies that may overcome these important limitations. The physicochemical properties of nanoparticles, such as particle size, shape and surface modification ligands, determine their targeting effectiveness. In this study, nanoparticles with different physicochemical properties were prepared to explore and confirm their targeting capacities to inflammatory prostate tissues of chronic bacterial prostatitis, focusing on the effects of size and different modification ligands on the targeting performance. and imaging results verified that folic acid-modified nanoparticles with a particle size of 180-190 nm via tail intravenous injection had the optimal targeting efficiency to prostate tissues. Our results provide an experimental basis and reference value for targeted therapy of prostate-related diseases with nanotechnology in the future.
慢性细菌性前列腺炎通常发生在男性身上，严重影响患者的生活质量。慢性细菌性前列腺炎的治疗效果受到游离药物（如抗生素）难以穿透前列腺上皮并靶向炎症组织的限制。纳米技术的出现为解决这一问题提供了可能性，例如开发靶向纳米颗粒递送策略，可能克服这些重要限制。纳米颗粒的物理化学性质，如粒径、形状和表面修饰配体，决定了它们的靶向效果。在本研究中，制备了具有不同物理化学性质的纳米颗粒，以探索并确认它们对慢性细菌性前列腺炎炎症前列腺组织的靶向能力，重点关注粒径和不同修饰配体对靶向性能的影响。成像结果证实，通过尾静脉注射的粒径为180 - 190 nm的叶酸修饰纳米颗粒对前列腺组织具有最佳靶向效率。我们的结果为未来利用纳米技术对前列腺相关疾病进行靶向治疗提供了实验依据和参考价值。
