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茄科(茄属)植物的糖苷生物碱作为潜在药物。

Glycoalkaloids of Plants in the Family Solanaceae (Nightshade) as Potential Drugs.

作者信息

Ostreikova T O, Kalinkina O V, Bogomolov N G, Chernykh I V

机构信息

I. P. Pavlov Ryazan State Medical University, Ministry of Health of the Russian Federation, 8 Vysokovol'tnaya St, Ryazan, 390026 Russia.

出版信息

Pharm Chem J. 2022;56(7):948-957. doi: 10.1007/s11094-022-02731-x. Epub 2022 Oct 18.

Abstract

Worldwide interest in medicinal plants and related drugs is growing because of the increased spectrum of new synthetic drugs. In this context, secondary plant metabolites are most significant. This review analyzes data on the structures and biosyntheses of metabolites such as glycoalkaloids; methods for their extraction from plants of the family Solanaceae, particularly potato ; their qualitative and quantitative analysis; biological activity; and toxicity. This information could be useful in the selection of methods for sample preparation and extraction of glycoalkaloids during the search for new plant sources with prospects of creating effective and safe pharmacological agents.

摘要

由于新型合成药物种类的增加,全球对药用植物及相关药物的兴趣与日俱增。在此背景下,植物次生代谢产物最为重要。本综述分析了诸如糖苷生物碱等代谢产物的结构和生物合成数据;从茄科植物尤其是马铃薯中提取它们的方法;它们的定性和定量分析;生物活性;以及毒性。这些信息可能有助于在寻找有前景开发有效且安全的药理剂的新植物来源过程中,选择糖苷生物碱的样品制备和提取方法。

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