Transformer With Double Enhancement for Low-Dose CT Denoising.

Increasingly serious health problems have made the usage of computed tomography surge. Therefore, algorithms for processing CT images are becoming more and more abundant. These algorithms can lessen the harm of cumulative radiation in CT technology for the patient while eliminating the noise of image caused by dose reduction. However, the mainstream CNN-based algorithms are inefficient when dealing with features in broad regions. Inspired by the large receptive field of transformer framework, this paper designs an end-to-end low-dose CT (LDCT) denoising network based on the transformer. The overall network contains a main branch and dual side branches. Specifically, the overlapping-free window-based self-attention transformer block is adopted on the main branch to realize image denoising. On the dual side branches, we propose double enhancement module to enrich edge, texture, and context information of LDCT images. Meanwhile, the receptive field of network is further enlarged after processing, which is helpful for building model's long-range dependencies. The outputs of the side branches are concatenated for enhancing information and generating high-quality CT images. In addition, to better train the network, we introduce a compound loss function including mean squared error (MSE), multi-scale perceptual (MSP), and Sobel-L1 (SL) to make the denoised image closer to the targeted norm-dose CT (NDCT) image. Lastly, we conducted experiments on two clinical datasets including abdomen, head, and chest LDCT images with 25%, 25%, and 10% of the full dose, respectively. The experimental results demonstrated that the proposed DEformer achieved better denoising performance than the existing algorithms.