Kinch Michael S, Kraft Zachary, Schwartz Tyler
Center for Research Innovation in Biotechnology, Long Island University, Brookville, NY 11548, USA.
Center for Research Innovation in Biotechnology, Long Island University, Brookville, NY 11548, USA.
Drug Discov Today. 2023 Jan;28(1):103415. doi: 10.1016/j.drudis.2022.103415. Epub 2022 Oct 21.
Monoclonal antibody products have risen from obscurity in the 1990s to a position that increasingly dominates both revenue generation and patient impact. This success has occurred largely over the past two decades, and we have identified factors associated with the remarkable advances that have contributed to the discovery, development and approval of monoclonal antibodies. Although consolidation has increased in recent years, the net number of monoclonal antibody developers continues to grow, bucking the general trend in the biopharmaceutical industry.
单克隆抗体产品已从20世纪90年代的默默无闻发展到如今在创收和患者影响方面日益占据主导地位。这一成功主要发生在过去二十年中，我们已经确定了与显著进展相关的因素，这些进展推动了单克隆抗体的发现、开发和批准。尽管近年来行业整合有所增加，但单克隆抗体开发商的净数量仍在持续增长，与生物制药行业的总体趋势背道而驰。
