霍奇金病患者心脏接受放疗后出现心肌肥厚、纤维化和梗死。
Myocardial hypertrophy, fibrosis and infarction following exposure of the heart to radiation for Hodgkin's disease.
作者信息
O'Donnell L, O'Neill T, Toner M, O'Briain S, Graham I
出版信息
Postgrad Med J. 1986 Nov;62(733):1055-8. doi: 10.1136/pgmj.62.733.1055.
Abstract
A 35 year old man was treated for stage IIA Hodgkin's disease by radiation to the upper thorax, axillae and neck. Three years later he presented with intractable and ultimately fatal congestive heart failure. Autopsy revealed massive biventricular hypertrophy with widespread subendocardial fibrosis and myocardial infarction, but with little coronary artery disease. Such a complex of features has not previously been described after radiation therapy and cannot be adequately explained by other known causes of heart muscle disease. Ventricular hypertrophy with extensive subendocardial fibrosis may be part of the spectrum of radiation heart disease.
摘要
一名35岁男性因IIA期霍奇金病接受了胸部上段、腋窝和颈部的放射治疗。三年后，他出现了难以治疗并最终致命的充血性心力衰竭。尸检显示双心室明显肥厚，伴有广泛的心内膜下纤维化和心肌梗死，但冠状动脉疾病较轻。这种特征组合在放射治疗后以前未曾有过描述，也无法用其他已知的心肌病病因来充分解释。伴有广泛心内膜下纤维化的心室肥厚可能是放射性心脏病范围的一部分。
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