用于治疗逼尿肌-尿道协同失调的长期α-肾上腺素能阻滞剂疗法。
Long-term alpha-adrenergic-blocking therapy in detrusor-urethra dyssynergia.
作者信息
Vereecken R L, Van Poppel H, Boeckx G, Leruitte A
出版信息
Eur Urol. 1983;9(3):167-9. doi: 10.1159/000474074.
PMID:6134620
Abstract
Neurogenic dyssynergia was treated with alpha-adrenergic blockers. Only 21 of 43 highly selected patients with residual urines and low flow rates continued therapy with phenoxybenzamine for more than 6 months, despite initial benefits. The causes of therapy discontinuation are discussed. A combination of 5 mg dibenzylin, 3 times daily, with parasympathomimetic drugs is often necessary. The mechanisms of action of alpha-adrenergic-blocking agents are discussed.
摘要
神经源性排尿协同失调采用α-肾上腺素能阻滞剂进行治疗。在43例经过严格挑选、存在残余尿且尿流率低的患者中，尽管起初有一定疗效，但仅有21例患者继续使用苯氧苄胺治疗超过6个月。文中讨论了治疗中断的原因。通常需要将每日3次、每次5毫克的双苄胺与拟副交感神经药物联合使用。文中还讨论了α-肾上腺素能阻滞剂的作用机制。
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