Durand S, Estival A, Vieu C, Clemente F, Douste-Blazy L
Pancreas. 1987;2(3):326-32. doi: 10.1097/00006676-198705000-00012.
We analyzed the lipid composition of the human pancreas and performed a parallel study on rat pancreas. Some precautions were taken in order to keep the secretory zymogens as inactive precursors in both tissues. The lipid content of the human pancreas corresponded to 5.5% of the tissue wet weight, lower than that found in pancreas of two-month-old Wistar rats (10%). In man, triglycerides and phospholipids were found at comparable levels, respectively, 37 and 30 mg/g of pancreas wet weight, not far from the values of the rat pancreas. In human pancreas, phosphatidylcholines and lysophosphatidylcholines represented about 40% of the total phospholipid fraction, phosphatidylethanolamines and lysophosphatidylethanolamines 21%, and phosphatidylserines and -inositols were found equally represented with 7.5%. The total cholesterol content accounted for about 4.5% of the total lipids; only 30% was esterified. By comparison, in rat, total cholesterol represented 3.3% of lipids and 90% was esterified. The phospholipids in human pancreas contained high amounts of saturated fatty acids (92%) mainly stearic and palmitic, whereas triglycerides contained equal amounts of saturated and unsaturated fatty acids, principally represented by oleic and palmitic acids. In rats the phospholipids contained only 63% saturated fatty acids (palmitic and stearic) and triglycerides contained 61% unsaturated fatty acids (mainly oleic and linoleic). In terms of lipid composition, there is a greater similarity between human and rat pancreas than with other known pancreas, such as the guinea pig and the ox.
我们分析了人类胰腺的脂质组成，并对大鼠胰腺进行了平行研究。为了使两种组织中的分泌性酶原保持无活性的前体状态，我们采取了一些预防措施。人类胰腺的脂质含量相当于组织湿重的5.5%，低于两个月大的Wistar大鼠胰腺中的脂质含量（10%）。在人类中，甘油三酯和磷脂的含量相当，分别为每克胰腺湿重37毫克和30毫克，与大鼠胰腺的值相差不大。在人类胰腺中，磷脂酰胆碱和溶血磷脂酰胆碱约占总磷脂部分的40%，磷脂酰乙醇胺和溶血磷脂酰乙醇胺占21%，磷脂酰丝氨酸和肌醇的含量均为7.5%。总胆固醇含量约占总脂质的4.5%；只有30%被酯化。相比之下，在大鼠中，总胆固醇占脂质的3.3%，90%被酯化。人类胰腺中的磷脂含有大量饱和脂肪酸（92%），主要是硬脂酸和棕榈酸，而甘油三酯中饱和脂肪酸和不饱和脂肪酸的含量相等，主要由油酸和棕榈酸代表。在大鼠中，磷脂仅含有63%的饱和脂肪酸（棕榈酸和硬脂酸），甘油三酯含有61%的不饱和脂肪酸（主要是油酸和亚油酸）。就脂质组成而言，人类和大鼠胰腺之间的相似性比与其他已知胰腺（如豚鼠和牛）之间的相似性更大。
