Ruggieri S, Fallani A
Lipids. 1979 Sep;14(9):781-8. doi: 10.1007/BF02533516.
The lipid composition of Morris hepatoma 5123c was analyzed together with that of liver and blood plasma from both normal and tumor-bearing rats. The results showed that the liver of tumor-bearing rats contained higher amounts of glycerides, choelsteryl esters, free fatty acids and phospholipids than the liver of normal rats. In the blood plasma of tumor-bearing rats, there was an increase of free cholesterol and triglycerides; this latter difference, however, was not statistically significant. Acyl chain changes in the liver of tumor-bearing rats consisted of an increase of palmitic and oleic acids and a decrease of stearic and arachidonic acids in phosphatidylinositol. Morris hepatoma 5123c contained a lower amount of triglycerides than the livers (both host and normal) and showed a significant decrease of total phospholipids when compared to the host liver. The major acyl chain changes found in Morris hepatoma 5123c compared with both normal and host rat livers were: a) a higher percentage of arachidonic acid together with a lower proportion of palmitic acid in cholesteryl esters; b) an increase of stearic and arachidonic acids and a decrease of palmitic acid in triglycerides; and c) a higher level of palmitic and oleic acids associated with a lower percentage of stearic and C22 polyunsaturated acids in phosphatidylcholine.
对 Morris 肝癌 5123c 的脂质组成，以及正常大鼠和荷瘤大鼠的肝脏及血浆的脂质组成进行了分析。结果显示，荷瘤大鼠肝脏中的甘油酯、胆固醇酯、游离脂肪酸和磷脂含量高于正常大鼠肝脏。在荷瘤大鼠的血浆中，游离胆固醇和甘油三酯有所增加；不过，后一种差异在统计学上并不显著。荷瘤大鼠肝脏中酰基链的变化包括磷脂酰肌醇中棕榈酸和油酸增加，硬脂酸和花生四烯酸减少。Morris 肝癌 5123c 中的甘油三酯含量低于肝脏（宿主肝脏和正常肝脏），并且与宿主肝脏相比，总磷脂显著减少。与正常大鼠和宿主大鼠肝脏相比，在 Morris 肝癌 5123c 中发现的主要酰基链变化如下：a）胆固醇酯中花生四烯酸的百分比更高，棕榈酸的比例更低；b）甘油三酯中硬脂酸和花生四烯酸增加，棕榈酸减少；c）磷脂酰胆碱中棕榈酸和油酸水平较高，硬脂酸和 C22 多不饱和酸的百分比较低。
