Departments of Internal Medicine, Food and Human Nutritional Sciences, University of Manitoba, Winnipeg, MB R3T 2N2, Canada.
School of Life Science, Shanghai University, Shanghai 200444, China.
J Agric Food Chem. 2022 Nov 9;70(44):14235-14246. doi: 10.1021/acs.jafc.2c06662. Epub 2022 Oct 25.
The constituents of germinated brown rice (GBR), brown rice (BRR), and white rice (WHR) and their impact on metabolism, inflammation, and gut microbiota in high fat (HF) diet-fed mice were examined. The contents of total fiber and γ-aminobutyric acid in BRR and GBR were higher than that in WHR ( < 0.05). Male C57 BL/6J mice received HF diet+26 g% of WHR, BRR, or GBR for 12 weeks. BRR and GBR comparably reduced HF diet-induced increases in fasting plasma glucose, lipids, insulin resistance, and inflammatory markers compared to WHR ( < 0.01). The abundance of fecal Bacteroidetes in mice fed HF+GBR or HF+BRR was higher than in HF+WHR-fed mice ( < 0.05). The abundance of fecal in GBR-fed mice was greater than that in WHR- or BRR-fed mice ( < 0.05). The results indicated that GBR or BRR attenuated hyperglycemia, insulin resistance, and inflammation in mice. HF+GBR, but not HF+BRR, increased a probiotic bacteria in the gut.
研究了发芽糙米（GBR）、糙米（BRR）和白米（WHR）的成分及其对高脂肪（HF）饮食喂养小鼠代谢、炎症和肠道微生物群的影响。BRR 和 GBR 中的总纤维和γ-氨基丁酸含量高于 WHR（<0.05）。雄性 C57BL/6J 小鼠接受 HF 饮食+26 g%的 WHR、BRR 或 GBR 喂养 12 周。与 WHR 相比，BRR 和 GBR 可降低 HF 饮食诱导的空腹血糖、血脂、胰岛素抵抗和炎症标志物的升高（<0.01）。与 HF+WHR 喂养的小鼠相比，喂养 HF+GBR 或 HF+BRR 的小鼠粪便中的拟杆菌门丰度更高（<0.05）。GBR 喂养的小鼠粪便中的丰度大于 WHR 或 BRR 喂养的小鼠（<0.05）。结果表明，GBR 或 BRR 可减轻小鼠的高血糖、胰岛素抵抗和炎症。HF+GBR 而非 HF+BRR 增加了肠道中的益生菌。
