Department of Metabolism, Digestion and Reproduction, St Mary's Hospital, Imperial College London, London, UK.
School of Biosciences, Cardiff University, Cardiff UK.
Gut Microbes. 2022 Jan-Dec;14(1):2138661. doi: 10.1080/19490976.2022.2138661.
Gastrostomy fed children traditionally have a Formulae diet (FD), which fulfills nutritional requirements; however, many families are adopting Blended diets (BD), which are what the whole family would eat. We undertook an observational investigation of the colonic microbiota and metabonome in a small group of gastrostomy fed children, who were either on an FD or BD, and compared, where possible to their siblings (17 FD, 28 BD, 19 HS). There was no increase in complications in tube blockage or infection rates, but a significant improvement in the prevalence of bowel problems, a reduction in medication and an increase in quality of life. Metataxonomic analysis showed that the FD group was significantly different to the Sibling group, and that families did not cluster together. Whole sample metabonomics showed no differences between groups; however, univariate analysis of biologically important metabolites did differ. Changing to a BD resulted in no increase in complications or risks, but improved the overall quality of life for the children and families.
经胃造口喂养的儿童传统上采用配方奶（FD），这可以满足营养需求；然而，许多家庭正在采用混合饮食（BD），这是全家人都吃的饮食。我们对一小部分经胃造口喂养的儿童的结肠微生物群和代谢组进行了观察性研究，这些儿童要么采用 FD，要么采用 BD，并尽可能与他们的兄弟姐妹（17 名 FD，28 名 BD，19 名 HS）进行比较。在管腔阻塞或感染率方面没有增加并发症，但肠病的患病率显著改善，药物减少，生活质量提高。分类组学分析表明，FD 组与兄弟姐妹组有显著差异，且家庭之间没有聚类。全样本代谢组学显示各组之间无差异；然而，对生物学上重要代谢物的单变量分析确实存在差异。改为 BD 不会增加并发症或风险，但可以提高儿童和家庭的整体生活质量。
