Cultech Limited, Unit 2 Christchurch Road, Baglan Industrial Park, Port Talbot, UK.
Department of Cellular Computational and Integrative Biology, University of Trento, Povo, Italy.
Sci Rep. 2021 Jan 6;11(1):5. doi: 10.1038/s41598-020-78285-3.
This 9-month randomised, parallel, double-blind, single-centre, placebo-controlled study (PROBE, ISRCTN18030882) assessed the impact of probiotic supplementation on bodyweight. Seventy overweight Bulgarian participants aged 45-65 years with BMI 25-29.9 kg/m received a daily dose of the Lab4P probiotic comprising lactobacilli and bifidobacteria (50 billion cfu/day). Participants maintained their normal diet and lifestyle over the duration of the study. The primary outcome was change from baseline in body weight and secondary outcomes included changes in waist circumference, hip circumference and blood pressure. A significant between group decrease in body weight (3.16 kg, 95% CI 3.94, 2.38, p < 0.0001) was detected favouring the probiotic group. Supplementation also resulted in significant between group decreases in waist circumference (2.58 cm, 95% CI 3.23, 1.94, p < 0.0001) and hip circumference (2.66 cm, 95% CI 3.28, 2.05, p < 0.0001) but no changes in blood pressure were observed. These findings support the outcomes of a previous shorter-term Lab4P intervention study in overweight and obese participants (PROMAGEN, ISRCTN12562026). We conclude that Lab4P has consistent weight modulation capability in free-living overweight adults.
这项为期 9 个月的随机、平行、双盲、单中心、安慰剂对照研究（PROBE，ISRCTN18030882）评估了益生菌补充对体重的影响。70 名超重的保加利亚参与者，年龄在 45-65 岁之间，BMI 为 25-29.9kg/m²，每天接受含有乳杆菌和双歧杆菌的 Lab4P 益生菌（每天 500 亿个菌落形成单位）。在研究期间，参与者保持正常的饮食和生活方式。主要结果是从基线到体重的变化，次要结果包括腰围、臀围和血压的变化。益生菌组体重显著下降（3.16kg，95%CI 3.94，2.38，p<0.0001）。补充益生菌还导致腰围（2.58cm，95%CI 3.23，1.94，p<0.0001）和臀围（2.66cm，95%CI 3.28，2.05，p<0.0001）显著降低，但血压无变化。这些发现支持之前一项关于超重和肥胖参与者的较短时间 Lab4P 干预研究的结果（PROMAGEN，ISRCTN12562026）。我们得出结论，Lab4P 对自由生活的超重成年人具有一致的体重调节能力。
