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评估在伊拉克纳杰夫从尿路感染患者中分离的β-内酰胺类和碳青霉烯类抗菌药物耐药性。

Assessment of ß-lactams and Carbapenems Antimicrobials Resistance in Isolated from Patients with Urinary Tract Infections in Najaf, Iraq.

机构信息

University of Kufa, Faculty of Science, Department of Biology, Kufa, Iraq.

University of Kufa, Faculty of Pharmacy, Department of Microbiology, Kufa, Iraq.

出版信息

Arch Razi Inst. 2022 Apr 30;77(2):669-673. doi: 10.22092/ARI.2022.356957.1947. eCollection 2022 Apr.

Abstract

Antimicrobial resistance is becoming an arising global issue. Until recent years, more than 50% of commercially available antibiotics were ß-lactam. Pathogenic bacteria which are resistant to antibiotics include all ß-lactams except for cephamycin and carbapenems. This study aimed to evaluate some ß-lactams and carbapenems antimicrobials resistance in . In total, 177 urinary tract infection samples were collected for the purposes of the study. Isolates were identified using morphological features and routine biochemical testing. All isolates were tested for susceptibility to 11 antibiotics using the usual disc diffusion method. The result showed that 155 (87.57%) and 20 (11.29%) out of 177 collected urine samples were gram-negative bacterial isolates and gram-positive bacterial isolates, respectively. The findings also showed that there were two samples (1.12 %) with no growth. The results proved no susceptibility to Ampicillin, Cloxacillin, Ceftazidime, Penicillin, Piperacillin with a resistance rate of 100%.

摘要

抗菌药物耐药性正在成为一个日益严重的全球问题。直到近年来,市场上供应的抗生素中超过 50%为β-内酰胺类抗生素。对各种β-内酰胺类抗生素(头孢菌素类和碳青霉烯类除外)均耐药的病原菌包括。本研究旨在评估一些β-内酰胺类和碳青霉烯类抗菌药物的耐药性。共采集了 177 份尿路感染样本用于研究。采用形态学特征和常规生化试验对分离物进行鉴定。采用常规纸片扩散法对所有分离物进行了 11 种抗生素的药敏试验。结果显示,在采集的 177 份尿液样本中,革兰氏阴性菌分离株和革兰氏阳性菌分离株分别为 155(87.57%)和 20(11.29%)。结果还显示,有两个样本(1.12%)没有生长。结果表明,氨苄西林、氯唑西林、头孢他啶、青霉素、哌拉西林无药敏性,耐药率均为 100%。

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