Department of Mechanical and Aerospace Engineering, University of California at Los Angeles, USA.
Department of Electrical and Computer Engineering, University of California at Los Angeles, USA.
Lab Chip. 2022 Nov 8;22(22):4327-4334. doi: 10.1039/d2lc00725h.
Acoustic patterning of micro-particles has many important biomedical applications. However, fabrication of such microdevices is costly and labor-intensive. Among conventional fabrication methods, photo-lithography provides high resolution but is expensive and time consuming, and not ideal for rapid prototyping and testing for academic applications. In this work, we demonstrate a highly efficient method for rapid prototyping of acoustic patterning devices using laser manufacturing. With this method we can fabricate a newly designed functional acoustic device in 4 hours. The acoustic devices fabricated using this method can achieve sub-wavelength, complex and non-periodic patterning of microparticles and biological objects with a spatial resolution of 60 μm across a large active manipulation area of 10 × 10 mm.
微颗粒的声图案化在许多重要的生物医学应用中都有重要作用。然而，此类微器件的制造既昂贵又耗费劳力。在传统的制造方法中，光光刻提供了高分辨率，但成本高且耗时，不适合学术应用的快速原型制作和测试。在这项工作中，我们展示了一种使用激光制造快速原型制作声图案化器件的高效方法。使用这种方法，我们可以在 4 小时内制造出一个新设计的功能声器件。使用这种方法制造的声器件可以实现亚波长、复杂和非周期性的微颗粒和生物物体的图案化，空间分辨率为 60μm，在 10×10mm 的大主动操作区域内。
