Cancer Institute, Xuzhou Medical University, Xuzhou, China.
Center of Clinical Oncology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, China.
Food Funct. 2022 Nov 14;13(22):11770-11779. doi: 10.1039/d2fo01673g.
Radiation therapy (RT) is a crucial part of many treatment plans for cancer patients. However, major undesired side effects are associated with this treatment, including impaired bone remodeling and bone loss. Irradiation induces bone loss due to promoted osteoclastic bone resorption and reduced osteoblastic bone formation. Astaxanthin (AST) is a natural antioxidant with anti-oxidative and anti-aging properties. However, it is unclear whether AST is also protective against osteoporosis induced by ionizing radiation (IR). Here, we evaluate the efficacy of AST in mitigating IR-induced bone loss in a mouse model where both hindlimbs received radiation. Reduced BMD, bone biomechanical strength, bone formation, elevated oxidative stress, and osteoclast activity with microarchitectural deterioration of trabecular and cortical bones were observed in IR mice. Supplementation with AST corrected these osteoporotic phenotypes, caused by IR, by inhibiting oxidative stress, DNA damage, osteocyte senescence, and senescence-associated secretory phenotype (SASP), subsequently promoting osteoblastic bone formation and inhibiting osteoclastic bone resorption. The results from our study provide experimental evidence for the clinical use of AST to prevent IR-induced osteoporosis in cancer patients.
放射治疗（RT）是癌症患者许多治疗计划的重要组成部分。然而，这种治疗方法伴随着严重的不良反应，包括骨重塑受损和骨丢失。辐射会导致骨丢失，这是由于破骨细胞骨吸收增加和成骨细胞骨形成减少所致。虾青素（AST）是一种天然抗氧化剂，具有抗氧化和抗衰老特性。然而，目前尚不清楚 AST 是否也能预防电离辐射（IR）引起的骨质疏松症。在这里，我们评估了 AST 在减轻小鼠模型中双侧后腿接受辐射引起的骨丢失中的疗效。IR 小鼠的骨密度（BMD）、骨生物力学强度、骨形成减少，氧化应激升高，破骨细胞活性增加，小梁骨和皮质骨的微观结构恶化。AST 的补充通过抑制氧化应激、DNA 损伤、骨细胞衰老和衰老相关分泌表型（SASP），随后促进成骨细胞骨形成和抑制破骨细胞骨吸收，纠正了由 IR 引起的这些骨质疏松表型。我们的研究结果为 AST 在预防癌症患者 IR 诱导的骨质疏松症中的临床应用提供了实验依据。
